SCOPe 2.06: Family a.26.1.3: Interferons/interleukin-10 (IL-10)

Lineage for Family a.26.1.3: Interferons/interleukin-10 (IL-10)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins)
   contains an additional helix in one of the crossover connections

Proteins:

1. Interferon-alpha 2a [47314] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47315] (9 PDB entries)

2. Interferon-alpha 2b [47312] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47313] (1 PDB entry)

3. Interferon-beta [47309] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [47310] (1 PDB entry)

   2. Species Mouse (Mus musculus) [TaxId:10090] [47311] (4 PDB entries)
      Uniprot P01575 22-182
      CA-atoms only

4. Interferon-gamma [47318] (3 species)
   intertwined dimer

   1. Species Cow (Bos taurus) [TaxId:9913] [47319] (3 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [47320] (4 PDB entries)

   3. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [47321] (1 PDB entry)

5. Interferon-tau [47316] (1 species)

   • Species Sheep (Ovis aries) [TaxId:9940] [47317] (1 PDB entry)

6. Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
   intertwined dimer, similar to interferon-gamma

   1. Species Epstein-Barr virus [TaxId:10376] [47308] (3 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [47307] (6 PDB entries)

   3. Species Human herpesvirus 5 [TaxId:10359] [74708] (1 PDB entry)

7. Interleukin-19 [81744] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [81745] (1 PDB entry)

8. Interleukin-22 (IL-22) [89036] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89037] (5 PDB entries)

9. automated matches [190141] (2 species)
   not a true protein

   1. Species Human (Homo sapiens) [TaxId:9606] [187124] (4 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [189956] (2 PDB entries)

More info for Family a.26.1.3: Interferons/interleukin-10 (IL-10)

Timeline for Family a.26.1.3: Interferons/interleukin-10 (IL-10):

• Family a.26.1.3: Interferons/interleukin-10 (IL-10) first appeared (with stable ids) in SCOP 1.55
  
• Family a.26.1.3: Interferons/interleukin-10 (IL-10) appears in SCOPe 2.05
  
• Family a.26.1.3: Interferons/interleukin-10 (IL-10) appears in SCOPe 2.07
  
• Family a.26.1.3: Interferons/interleukin-10 (IL-10) appears in the current release, SCOPe 2.08