SCOPe 2.02: Protein: Interleukin-2 (IL-2)

Lineage for Protein: Interleukin-2 (IL-2)

Root: SCOPe 2.02
Class a: All alpha proteins [46456] (284 folds)
Fold a.26: 4-helical cytokines [47265] (1 superfamily)
core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
there are two different topoisomers of this fold with different entanglements of the two crossover connections
Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)
Protein Interleukin-2 (IL-2) [47301] (1 species)

Species:

Human (Homo sapiens) [TaxId:9606] [47302] (15 PDB entries)

Domain for 1irl:
- Domain d1irla_: 1irl A: [16883]
  mutant
Domain for 1m47:
- Domain d1m47a_: 1m47 A: [74442]
  complexed with so4
Domains for 1m48:
1. Domain d1m48a_: 1m48 A: [74443]
  complexed with frg
2. Domain d1m48b_: 1m48 B: [74444]
  complexed with frg
Domains for 1m49:
1. Domain d1m49a_: 1m49 A: [74445]
  complexed with cmm
2. Domain d1m49b_: 1m49 B: [74446]
  complexed with cmm
Domain for 1m4a:
- Domain d1m4aa_: 1m4a A: [74447]
  complexed with gol, mpe
Domain for 1m4b:
- Domain d1m4ba_: 1m4b A: [74448]
  complexed with nmp
Domains for 1m4c:
1. Domain d1m4ca_: 1m4c A: [74449]
2. Domain d1m4cb_: 1m4c B: [74450]
Domain for 1nbp:
- Domain d1nbpa_: 1nbp A: [80392]
  complexed with mhc, so4
Domains for 1pw6:
1. Domain d1pw6a_: 1pw6 A: [95200]
  complexed with a small molecule inhibitor
  complexed with frb, so4
2. Domain d1pw6b_: 1pw6 B: [95201]
  complexed with a small molecule inhibitor
  complexed with frb, so4
Domains for 1py2:
1. Domain d1py2a_: 1py2 A: [95319]
  complexed with a small molecule inhibitor
  complexed with frh, zn
2. Domain d1py2b_: 1py2 B: [95320]
  complexed with a small molecule inhibitor
  complexed with frh, zn
3. Domain d1py2c_: 1py2 C: [95321]
  complexed with a small molecule inhibitor
  complexed with frh, zn
4. Domain d1py2d_: 1py2 D: [95322]
  complexed with a small molecule inhibitor
  complexed with frh, zn
Domains for 1qvn:
1. Domain d1qvna_: 1qvn A: [161678]
  automated match to d1irla_
  complexed with fri, zn
2. Domain d1qvnb_: 1qvn B: [161679]
  automated match to d1irla_
  complexed with fri, zn
3. Domain d1qvnc_: 1qvn C: [161680]
  automated match to d1irla_
  complexed with fri, zn
4. Domain d1qvnd_: 1qvn D: [161681]
  automated match to d1irla_
  complexed with fri, zn
Domain for 1z92:
- Domain d1z92a_: 1z92 A: [124737]
  Other proteins in same PDB: d1z92b1, d1z92b2
  automated match to d1irl__
Domain for 2b5i:
- Domain d2b5ia_: 2b5i A: [127895]
  Other proteins in same PDB: d2b5ib1, d2b5ib2, d2b5ic1, d2b5ic2, d2b5id1, d2b5id2
  automated match to d1irl__
  complexed with nag

Domains for 2erj:

Domain d2erjd1: 2erj D:6-133 [132294]
Other proteins in same PDB: d2erja1, d2erja2, d2erjb1, d2erjb2, d2erjc1, d2erjc2, d2erje1, d2erje2, d2erjf1, d2erjf2, d2erjg1, d2erjg2
automatically matched to d3inkc_
complexed with nag

Domain d2erjh1: 2erj H:6-133 [132301]
Other proteins in same PDB: d2erja1, d2erja2, d2erjb1, d2erjb2, d2erjc1, d2erjc2, d2erje1, d2erje2, d2erjf1, d2erjf2, d2erjg1, d2erjg2
automatically matched to d3inkc_
complexed with nag

Domains for 3ink:
1. Domain d3inkc_: 3ink C: [16881]
2. Domain d3inkd_: 3ink D: [16882]

More info for Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines

Timeline for Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines:

Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines first appeared (with stable ids) in SCOP 1.55
Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines appears in SCOPe 2.01
Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines appears in SCOPe 2.03
Protein Interleukin-2 (IL-2) from a.26.1.2: Short-chain cytokines appears in the current release, SCOPe 2.08