SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family a.26.1.2: Short-chain cytokines

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 1991528Family a.26.1.2: Short-chain cytokines [47286] (14 protein domains)

Protein Domains:

  1. 1991529Erythropoietin [47287] (1 species)
    long chain cytokine with a short-chain cytokine topology
  2. 1991534Flt3 ligand [47297] (1 species)
    forms dimer similar to the M-CSF and SCF dimers
  3. 1991540Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289] (1 species)
  4. 1991554Interleukin-13 (IL-13) [63532] (1 species)
  5. 1991569Interleukin-15 (IL-15) [158422] (2 species)
    1. 1991570Species Human (Homo sapiens) [TaxId:9606] [158423] (3 PDB entries)
      Uniprot P40933 49-162
    2. 1991582Species Mouse (Mus musculus) [TaxId:10090] [158424] (1 PDB entry)
      Uniprot P48346 49-162
  6. 1991585Interleukin-2 (IL-2) [47301] (1 species)
  7. 1991622Interleukin-21 (IL-21) [158425] (1 species)
  8. 1991633Interleukin-3 (IL-3) [47303] (1 species)
  9. 1991636Interleukin-4 (IL-4) [47291] (1 species)
  10. 1991654Interleukin-5 [47293] (1 species)
    intertwined dimer
  11. 1991658Macrophage colony-stimulating factor (M-CSF) [47295] (1 species)
    forms dimer similar to the Flt3 ligand and SCF dimers
  12. 1991662Stem cell factor, SCF [47299] (1 species)
    forms dimer similar to the M-CSF and Flt3 ligand dimers
  13. 1991673Thrombopoietin [101140] (1 species)
    long chain cytokine with a short-chain cytokine topology
  14. 1991681automated matches [190501] (4 species)
    not a true protein
    1. 1991682Species Human (Homo sapiens) [TaxId:9606] [187448] (16 PDB entries)
    2. 1991713Species Mouse (Mus musculus) [TaxId:10090] [187941] (5 PDB entries)
    3. 1991726Species Mustela putorius [TaxId:9669] [279075] (1 PDB entry)
    4. 2282881Species Ovis aries [TaxId:9940] [326182] (2 PDB entries)

More info for Family a.26.1.2: Short-chain cytokines

Timeline for Family a.26.1.2: Short-chain cytokines: