Lineage for Family a.26.1.2: Short-chain cytokines

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 1991528Family a.26.1.2: Short-chain cytokines [47286] (14 protein domains)

Protein Domains:

  1. 1991529Erythropoietin [47287] (1 species)
    long chain cytokine with a short-chain cytokine topology
  2. 1991534Flt3 ligand [47297] (1 species)
    forms dimer similar to the M-CSF and SCF dimers
  3. 1991540Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289] (1 species)
  4. 1991554Interleukin-13 (IL-13) [63532] (1 species)
  5. 1991569Interleukin-15 (IL-15) [158422] (2 species)
    1. 1991570Species Human (Homo sapiens) [TaxId:9606] [158423] (3 PDB entries)
      Uniprot P40933 49-162
    2. 1991582Species Mouse (Mus musculus) [TaxId:10090] [158424] (1 PDB entry)
      Uniprot P48346 49-162
  6. 1991585Interleukin-2 (IL-2) [47301] (1 species)
  7. 1991622Interleukin-21 (IL-21) [158425] (1 species)
  8. 1991633Interleukin-3 (IL-3) [47303] (1 species)
  9. 1991636Interleukin-4 (IL-4) [47291] (1 species)
  10. 1991654Interleukin-5 [47293] (1 species)
    intertwined dimer
  11. 1991658Macrophage colony-stimulating factor (M-CSF) [47295] (1 species)
    forms dimer similar to the Flt3 ligand and SCF dimers
  12. 1991662Stem cell factor, SCF [47299] (1 species)
    forms dimer similar to the M-CSF and Flt3 ligand dimers
  13. 1991673Thrombopoietin [101140] (1 species)
    long chain cytokine with a short-chain cytokine topology
  14. 1991681automated matches [190501] (4 species)
    not a true protein
    1. 1991682Species Human (Homo sapiens) [TaxId:9606] [187448] (17 PDB entries)
    2. 1991713Species Mouse (Mus musculus) [TaxId:10090] [187941] (5 PDB entries)
    3. 1991726Species Mustela putorius [TaxId:9669] [279075] (1 PDB entry)
    4. 2282881Species Ovis aries [TaxId:9940] [326182] (2 PDB entries)

More info for Family a.26.1.2: Short-chain cytokines

Timeline for Family a.26.1.2: Short-chain cytokines: