SCOPe 2.04: Protein: Interleukin-6

Root: SCOPe 2.04
Class a: All alpha proteins [46456] (285 folds)
Fold a.26: 4-helical cytokines [47265] (1 superfamily)
core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
there are two different topoisomers of this fold with different entanglements of the two crossover connections
Family a.26.1.1: Long-chain cytokines [47267] (10 proteins)
Protein Interleukin-6 [47272] (2 species)

Human (Homo sapiens) [TaxId:9606] [47273] (7 PDB entries)
1. Domain for 1alu:
  - Domain d1alua_: 1alu A: [16826]
    complexed with so4, tla
2. Domain for 1il6:
  - Domain d1il6a_: 1il6 A: [16827]
3. Domain for 1p9m:
  - Domain d1p9mb_: 1p9m B: [87994]
    Other proteins in same PDB: d1p9ma1, d1p9ma2, d1p9ma3, d1p9mc1, d1p9mc2
4. Domain for 2il6:
  - Domain d2il6a_: 2il6 A: [16828]
5. Domains for 4cni:
  1. Domain d4cnic_: 4cni C: [256633]
    Other proteins in same PDB: d4cnib1, d4cnib2
    automated match to d4ni9a_
    complexed with so4, tam
  2. Domain d4cnid_: 4cni D: [256634]
    Other proteins in same PDB: d4cnib1, d4cnib2
    automated match to d4ni9a_
    complexed with so4, tam
6. Domain for 4ni7:
  - Domain d4ni7a_: 4ni7 A: [236231]
    automated match to d1alua_
    protein/DNA complex; complexed with na
7. Domains for 4ni9:
  1. Domain d4ni9a_: 4ni9 A: [236232]
    automated match to d1alua_
    protein/DNA complex; complexed with na
  2. Domain d4ni9c_: 4ni9 C: [236233]
    automated match to d1alua_
    protein/DNA complex; complexed with na
Human herpesvirus 8, Kaposi's sarcoma herpes-virus [TaxId:37296] [63528] (1 PDB entry)
- Domain for 1i1r:
  - Domain d1i1rb_: 1i1r B: [61548]
    Other proteins in same PDB: d1i1ra1, d1i1ra2, d1i1ra3

Timeline for Protein Interleukin-6 from a.26.1.1: Long-chain cytokines:

Protein Interleukin-6 from a.26.1.1: Long-chain cytokines first appeared (with stable ids) in SCOP 1.55
Protein Interleukin-6 from a.26.1.1: Long-chain cytokines appears in SCOPe 2.03
Protein Interleukin-6 from a.26.1.1: Long-chain cytokines appears in SCOPe 2.05
Protein Interleukin-6 from a.26.1.1: Long-chain cytokines appears in the current release, SCOPe 2.08