SCOPe 2.01: Superfamily a.26.1: 4-helical cytokines

Lineage for Superfamily a.26.1: 4-helical cytokines

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (3 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

Families:

1. a.26.1.1: Long-chain cytokines [47267] (10 proteins)

2. a.26.1.2: Short-chain cytokines [47286] (14 proteins)

3. a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins)
   contains an additional helix in one of the crossover connections

More info for Superfamily a.26.1: 4-helical cytokines

Timeline for Superfamily a.26.1: 4-helical cytokines:

• Superfamily a.26.1: 4-helical cytokines first appeared (with stable ids) in SCOP 1.55
  
• Superfamily a.26.1: 4-helical cytokines appears in SCOP 1.75
  
• Superfamily a.26.1: 4-helical cytokines appears in SCOPe 2.02
  
• Superfamily a.26.1: 4-helical cytokines appears in the current release, SCOPe 2.08