SCOPe 2.08: Protein: Vinculin

Lineage for Protein: Vinculin

Root: SCOPe 2.08
Class a: All alpha proteins [46456] (290 folds)
Fold a.24: Four-helical up-and-down bundle [47161] (29 superfamilies)
core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down
Superfamily a.24.9: alpha-catenin/vinculin-like [47220] (2 families)

Family a.24.9.1: alpha-catenin/vinculin [47221] (3 proteins)
possible duplication: contains several domains of this fold
The listed PDB entries contain different large fragments but not the whole proteins

Protein Vinculin [47224] (2 species)

Species:

Chicken (Gallus gallus) [TaxId:9031] [47225] (3 PDB entries)
Uniprot P12003

Domains for 1qkr:
1. Domain d1qkra_: 1qkr A: [16628]
  tail domain
  complexed with so4
2. Domain d1qkrb_: 1qkr B: [16629]
  tail domain
  complexed with so4

Domains for 1st6:

Domain d1st6a1: 1st6 A:1-125 [106000]
Other proteins in same PDB: d1st6a9
full-length protein containing eight four-helix bundle domains
Domain d1st6a2: 1st6 A:126-252 [106001]
Other proteins in same PDB: d1st6a9
full-length protein containing eight four-helix bundle domains
Domain d1st6a3: 1st6 A:253-371 [106002]
Other proteins in same PDB: d1st6a9
full-length protein containing eight four-helix bundle domains
Domain d1st6a4: 1st6 A:372-488 [106003]
Other proteins in same PDB: d1st6a9
full-length protein containing eight four-helix bundle domains
Domain d1st6a5: 1st6 A:489-646 [106004]
Other proteins in same PDB: d1st6a9
full-length protein containing eight four-helix bundle domains

Domain d1st6a6: 1st6 A:647-718 [106005]
Other proteins in same PDB: d1st6a9
full-length protein containing eight four-helix bundle domains
fragment; missing more than one-third of the common structure and/or sequence

Domain d1st6a7: 1st6 A:719-855 [106006]
Other proteins in same PDB: d1st6a9
full-length protein containing eight four-helix bundle domains
Domain d1st6a8: 1st6 A:875-1065 [106007]
Other proteins in same PDB: d1st6a9
full-length protein containing eight four-helix bundle domains

Domains for 1t01:
1. Domain d1t01a1: 1t01 A:1-125 [106188]
  Other proteins in same PDB: d1t01a3
  complexed with Talin 1 fragment (Uniprot P26039 605-628), chain B
2. Domain d1t01a2: 1t01 A:126-252 [106189]
  Other proteins in same PDB: d1t01a3
  complexed with Talin 1 fragment (Uniprot P26039 605-628), chain B

Human (Homo sapiens) [TaxId:9606] [101111] (16 PDB entries)
Uniprot P18206 1-257
1. Domains for 1rkc:
  1. Domain d1rkca1: 1rkc A:1-128 [97606]
    head domain; contains two domains of this fold; complexed with talin fragment, chain B
  2. Domain d1rkca2: 1rkc A:129-258 [97607]
    head domain; contains two domains of this fold; complexed with talin fragment, chain B
2. Domains for 1rke:
  1. Domain d1rkea1: 1rke A:1-128 [97608]
    Other proteins in same PDB: d1rkea3
    head domain; contains two domains of this fold; complexed with separate tail domain of the same or closely related protein
  2. Domain d1rkea2: 1rke A:129-258 [97609]
    Other proteins in same PDB: d1rkea3
    head domain; contains two domains of this fold; complexed with separate tail domain of the same or closely related protein
  3. Domain d1rkeb_: 1rke B: [97610]
    Other proteins in same PDB: d1rkea3
    tail domain; complexed with separate head domain of the same or closely related protein
3. Domains for 1syq:
  1. Domain d1syqa1: 1syq A:1-128 [106124]
    Other proteins in same PDB: d1syqa3
    head domain; contains two domains of this fold; complexed with talin fragment, chain B (Uniprot Q9Y490 607-631)
  2. Domain d1syqa2: 1syq A:129-257 [106125]
    Other proteins in same PDB: d1syqa3
    head domain; contains two domains of this fold; complexed with talin fragment, chain B (Uniprot Q9Y490 607-631)
4. Domain for 3myi:
  - Domain d3myia_: 3myi A: [265073]
    automated match to d3vf0a_
5. Domains for 3s90:
  1. Domain d3s90a1: 3s90 A:3-128 [233515]
    automated match to d1syqa1
  2. Domain d3s90a2: 3s90 A:129-250 [233516]
    automated match to d1rkea2
  3. Domain d3s90b1: 3s90 B:2-128 [233517]
    automated match to d1syqa1
  4. Domain d3s90b2: 3s90 B:129-252 [233518]
    automated match to d1rkea2
6. Domains for 3tj5:
  1. Domain d3tj5a1: 3tj5 A:2-128 [233688]
    automated match to d1syqa1
    complexed with gol
  2. Domain d3tj5a2: 3tj5 A:129-255 [233707]
    automated match to d1rkea2
    complexed with gol
7. Domains for 3tj6:
  1. Domain d3tj6a1: 3tj6 A:1-128 [233689]
    automated match to d1syqa1
  2. Domain d3tj6a2: 3tj6 A:129-257 [233708]
    automated match to d1rkea2
8. Domain for 3vf0:
  - Domain d3vf0a_: 3vf0 A: [250537]
    automated match to d1qkrb_
    complexed with epe, gol; mutant
9. Domains for 4dj9:
  1. Domain d4dj9a1: 4dj9 A:3-128 [251460]
    automated match to d3rf3b1
  2. Domain d4dj9a2: 4dj9 A:129-254 [251461]
    automated match to d3rf3b2
10. Domains for 4ehp:
  1. Domain d4ehpa1: 4ehp A:2-128 [251757]
    automated match to d3s90b1
    complexed with act
  2. Domain d4ehpa2: 4ehp A:129-252 [251758]
    automated match to d3s90b2
    complexed with act
11. Domains for 5l0c:
  1. Domain d5l0ca_: 5l0c A: [322052]
    automated match to d3vf0a_
    complexed with pio, po4
  2. Domain d5l0cb_: 5l0c B: [321939]
    automated match to d3vf0a_
    complexed with pio, po4
  3. Domain d5l0cc_: 5l0c C: [322005]
    automated match to d3vf0a_
    complexed with pio, po4
  4. Domain d5l0cd_: 5l0c D: [321981]
    automated match to d3vf0a_
    complexed with pio, po4
12. Domains for 5l0d:
  1. Domain d5l0da_: 5l0d A: [321940]
    automated match to d3vf0a_
    complexed with pio
  2. Domain d5l0db_: 5l0d B: [322021]
    automated match to d3vf0a_
    complexed with pio
  3. Domain d5l0dc_: 5l0d C: [321989]
    automated match to d3vf0a_
    complexed with pio
  4. Domain d5l0dd_: 5l0d D: [322015]
    automated match to d3vf0a_
    complexed with pio
13. Domains for 5l0f:
  1. Domain d5l0fa_: 5l0f A: [321933]
    automated match to d3vf0a_
    complexed with gol; mutant
  2. Domain d5l0fb_: 5l0f B: [322002]
    automated match to d3vf0a_
    complexed with gol; mutant
14. Domain for 5l0h:
  - Domain d5l0ha_: 5l0h A: [322048]
    automated match to d3vf0a_
    complexed with peg, pio, po4; mutant
15. Domain for 5l0i:
  - Domain d5l0ia_: 5l0i A: [321999]
    automated match to d3vf0a_
    complexed with gol, na; mutant
16. Domains for 5y04:
  1. Domain d5y04a1: 5y04 A:1-128 [349538]
    automated match to d1syqa1
  2. Domain d5y04a2: 5y04 A:129-250 [349539]
    automated match to d1rkea2

More info for Protein Vinculin from a.24.9.1: alpha-catenin/vinculin

Timeline for Protein Vinculin from a.24.9.1: alpha-catenin/vinculin:

Protein Vinculin from a.24.9.1: alpha-catenin/vinculin first appeared (with stable ids) in SCOP 1.55, called Protein Vinculin, tail domain from a.24.9.1: alpha-catenin/vinculin
Protein Vinculin from a.24.9.1: alpha-catenin/vinculin appears in SCOPe 2.07