Lineage for Fold a.24: Four-helical up-and-down bundle

  1. Root: SCOP 1.67
  2. 349259Class a: All alpha proteins [46456] (202 folds)
  3. 353428Fold a.24: Four-helical up-and-down bundle [47161] (20 superfamilies)
    core: 4 helices; bundle, closed or partly opened, left-handed twist; up-and-down

Superfamilies:

  1. 353429a.24.1: Apolipoprotein [47162] (1 family) (S)
  2. 353447a.24.2: Aspartate receptor, ligand-binding domain [47170] (1 family) (S)
  3. 353463a.24.3: Cytochromes [47175] (2 families) (S)
    Heme-containing proteins
  4. 353512a.24.4: Hemerythrin [47188] (1 family) (S)
  5. 353555a.24.5: TMV-like viral coat proteins [47195] (1 family) (S)
  6. 353569a.24.7: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) [47212] (1 family) (S)
  7. 353580a.24.8: Proteasome activator reg(alpha) [47216] (1 family) (S)
  8. 353591a.24.9: alpha-catenin/vinculin [47220] (1 family) (S)
  9. 353618a.24.10: Histidine-containing phosphotransfer domain, HPT domain [47226] (3 families) (S)
    contains additional, fifth helix at the N-terminus
  10. 353651a.24.11: Bacterial GAP domain [47233] (1 family) (S)
    contains extra helices in the loops at one end of the bundle
  11. 353666a.24.12: Outer surface protein C (OspC) [63515] (1 family) (S)
  12. 353679a.24.13: Domain of the SRP/SRP receptor G-proteins [47364] (1 family) (S)
  13. 353715a.24.14: FAT domain of focal adhesion kinase [68993] (1 family) (S)
  14. 353737a.24.15: FAD-dependent thiol oxidase [69000] (1 family) (S)
  15. 353753a.24.16: Nucleotidyltransferase substrate binding subunit/domain [81593] (3 families) (S)
  16. 353778a.24.17: Group V grass pollen allergen [81736] (1 family) (S)
  17. 353799a.24.18: Oxygen-evolving enhancer protein 3, [101112] (1 family) (S)
  18. 353804a.24.19: Flagellar export chaperone FliS [101116] (1 family) (S)
    can form closed, open and helix-swapped bundles
  19. 353816a.24.20: Colicin D immunity protein [101125] (1 family) (S)
  20. 353821a.24.21: RecG, N-terminal domain [69008] (1 family) (S)

More info for Fold a.24: Four-helical up-and-down bundle

Timeline for Fold a.24: Four-helical up-and-down bundle: