Lineage for Superfamily a.4.5: "Winged helix" DNA-binding domain

  1. Root: SCOP 1.69
  2. 436025Class a: All alpha proteins [46456] (218 folds)
  3. 438099Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (13 superfamilies)
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  4. 438531Superfamily a.4.5: "Winged helix" DNA-binding domain [46785] (55 families) (S)
    contains a small beta-sheet (wing)

Families:

  1. 438532a.4.5.1: Biotin repressor-like [46786] (2 proteins)
  2. 438542a.4.5.2: LexA repressor, N-terminal DNA-binding domain [46789] (1 protein)
  3. 438549a.4.5.3: Arginine repressor (ArgR), N-terminal DNA-binding domain [46792] (1 protein)
  4. 438567a.4.5.4: CAP C-terminal domain-like [46796] (3 proteins)
  5. 438601a.4.5.5: ArsR-like transcriptional regulators [46801] (2 proteins)
    The N- and C-terminal helical extensions to the common fold form the dimer interface
  6. 438620a.4.5.6: GntR-like transcriptional regulators [46804] (1 protein)
  7. 438631a.4.5.7: Replication terminator protein (RTP) [46807] (1 protein)
  8. 438640a.4.5.8: N-terminal domain of molybdate-dependent transcriptional regulator ModE [46810] (1 protein)
    contains beta-hairpin in the N-terminal extension and two helices in the C-terminal extension
  9. 438651a.4.5.9: Transcription factor MotA, activation domain [46813] (1 protein)
    The N- and C-terminal helical extensions to the common fold form the dimer interface (distinct from that of ArsR-like family)
  10. 438657a.4.5.10: Replication initiation protein [46816] (2 proteins)
    duplication: tandem repeat of two "winged helix" domains arranged with the pseudo twofold symmetry
  11. 438666a.4.5.11: Helicase DNA-binding domain [46819] (2 proteins)
    follows the extended AAA-ATPase domain
  12. 438684a.4.5.12: Restriction endonuclease FokI, N-terminal (recognition) domain [46824] (1 protein)
  13. 438696a.4.5.13: Linker histone H1/H5 [46827] (3 proteins)
  14. 438709a.4.5.14: Forkhead DNA-binding domain [46832] (5 proteins)
  15. 438726a.4.5.15: DNA-binding domain from rap30 [46841] (1 protein)
  16. 438731a.4.5.16: C-terminal domain of RPA32 [46844] (1 protein)
  17. 438735a.4.5.17: Cell cycle transcription factor e2f-dp [46847] (2 proteins)
    heterodimer of two homologous chains
  18. 438742a.4.5.18: The central core domain of TFIIE beta [46850] (1 protein)
  19. 438747a.4.5.19: Z-DNA binding domain [46853] (4 proteins)
    Pfam 02295
  20. 438764a.4.5.20: P4 origin-binding domain-like [46856] (2 proteins)
    C-terminus passes through the first loop
  21. 438776a.4.5.21: ets domain [46859] (6 proteins)
  22. 438816a.4.5.22: Heat-shock transcription factor [46873] (1 protein)
  23. 438836a.4.5.23: Interferon regulatory factor [46877] (2 proteins)
  24. 438851a.4.5.24: Iron-dependent repressor protein [46882] (3 proteins)
  25. 438896a.4.5.25: Methionine aminopeptidase, insert domain [46887] (1 protein)
    circularly permuted version of the "winged helix" fold
  26. 438914a.4.5.27: TnsA endonuclease, C-terminal domain [46782] (1 protein)
  27. 438919a.4.5.28: MarR-like transcriptional regulators [63379] (8 proteins)
    The N- and C-terminal helical extensions to the common fold form the dimer interface
  28. 438956a.4.5.29: Plant O-methyltransferase, N-terminal domain [63475] (5 proteins)
    unknown function
  29. 438983a.4.5.30: C-terminal domain of the rap74 subunit of TFIIF [63480] (1 protein)
  30. 438990a.4.5.31: DEP domain [63483] (4 proteins)
    membrane-binding domain
  31. 439003a.4.5.32: Lrp/AsnC-like transcriptional regulator N-terminal domain [68967] (2 proteins)
    Swapped dimer with the "wing" C-terminal strands
  32. 439011a.4.5.33: Transcriptional regulator IclR, N-terminal domain [74676] (1 protein)
  33. 439016a.4.5.34: SCF ubiquitin ligase complex WHB domain [74679] (2 proteins)
  34. 439029a.4.5.35: C-terminal fragment of elongation factor SelB [74683] (1 protein)
  35. 439036a.4.5.36: DNA-binding protein Mj223 [81690] (1 protein)
    homologous to the MarR-like family in the DNA-binding region but dimerizes differently through the N- and C-terminal helical extensions to the common fold
  36. 439041a.4.5.37: LysR-like transcriptional regulators [88979] (1 protein)
    contains long helix in the C-terminal extension; forms dimer similar to the RTP dimer
  37. 439050a.4.5.38: Transcriptional repressor Rex, N-terminal domain [101007] (1 protein)
  38. 439060a.4.5.39: Penicillinase repressor [101016] (2 proteins)
    homologous to the MarR-like family in the DNA-binding region but has a different dimerisation subdomain
  39. 439077a.4.5.40: N-terminal domain of Bacillus PurR [101021] (1 protein)
  40. 439088a.4.5.41: Transcription factor E/IIe-alpha, N-terminal domain [101024] (1 protein)
    contains extra N-terminal helix
  41. 439092a.4.5.42: FUR-like [101027] (1 protein)
    contains extra N-terminal helix and an alpha+beta dimerisation subdomain
  42. 439096a.4.5.43: DNA helicase RecQ DNA-binding domain [101030] (1 protein)
    follows the tandem AAA-ATPase domain
  43. 439101a.4.5.44: 39 kda initiator binding protein, IBP39, N-terminal domain [101045] (1 protein)
  44. 439111a.4.5.45: Dissimilatory sulfite reductase DsvD [101048] (1 protein)
  45. 439116a.4.5.46: La domain [101051] (1 protein)
    Pfam 05383; RNA-binding domain
  46. 439122a.4.5.47: PCI domain (PINT motif, Pfam 01399) [109671] (1 protein)
  47. 439126a.4.5.48: Hypothetical protein F93 [109674] (1 protein)
    contains long helix in the C-terminal extension; forms dimer similar to the RTP and LysR dimers
  48. 439131a.4.5.49: Archaeal DNA-binding protein [109677] (1 protein)
    contains long helix in the C-terminal extension; forms dimer similar to the RTP and LysR dimers
  49. 439135a.4.5.50: Hypothetical protein AF2008 [109680] (1 protein)
    The N- and C-terminal helical extensions to the common fold form the dimer interface, distinct from other known families
  50. 439140a.4.5.51: Heat-inducible transcription repressor HrcA, N-terminal domain [109683] (1 protein)
    similar domain organization to the transcriptional regulator IclR
  51. 439146a.4.5.52: DNA replication factor Cdt1 [109686] (1 protein)
  52. 439151a.4.5.53: Eukaryotic translation initiation factor 3 subunit 12, eIF3k, C-terminal domain [109689] (1 protein)
    C-terminal part of Pfam 06272
  53. 439155a.4.5.54: Vacuolar sorting protein domain [109692] (3 proteins)
    duplication: tandem repeat of two "winged-helix" domains
  54. 439170a.4.5.55: Transcriptional regulator Rrf2 (Pfam 02082) [109699] (1 protein)
  55. 439174a.4.5.56: Rio2 serine protein kinase N-terminal domain [109702] (1 protein)

More info for Superfamily a.4.5: "Winged helix" DNA-binding domain

Timeline for Superfamily a.4.5: "Winged helix" DNA-binding domain: