Lineage for Superfamily a.4.5: "Winged helix" DNA-binding domain

  1. Root: SCOP 1.67
  2. 349259Class a: All alpha proteins [46456] (202 folds)
  3. 351236Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (12 superfamilies)
    core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
  4. 351617Superfamily a.4.5: "Winged helix" DNA-binding domain [46785] (45 families) (S)
    contains a small beta-sheet (wing)

Families:

  1. 351618a.4.5.1: Biotin repressor-like [46786] (2 proteins)
  2. 351628a.4.5.2: LexA repressor, N-terminal DNA-binding domain [46789] (1 protein)
  3. 351635a.4.5.3: Arginine repressor (ArgR), N-terminal DNA-binding domain [46792] (1 protein)
  4. 351653a.4.5.4: CAP C-terminal domain-like [46796] (3 proteins)
  5. 351687a.4.5.5: ArsR-like transcriptional regulators [46801] (1 protein)
    The N- and C-terminal helical extensions to the common fold form the dimer interface
  6. 351692a.4.5.6: GntR-like transcriptional regulators [46804] (1 protein)
  7. 351703a.4.5.7: Replication terminator protein (RTP) [46807] (1 protein)
  8. 351712a.4.5.8: N-terminal domain of molybdate-dependent transcriptional regulator ModE [46810] (1 protein)
    contains beta-hairpin in the N-terminal extension and two helices in the C-terminal extension
  9. 351723a.4.5.9: Transcription factor MotA, activation domain [46813] (1 protein)
    The N- and C-terminal helical extensions to the common fold form the dimer interface (distinct from that of ArsR-like family)
  10. 351729a.4.5.10: Replication initiation protein [46816] (2 proteins)
    duplication: tandem repeat of two "winged helix" domains arranged with the pseudo twofold symmetry
  11. 351738a.4.5.11: Helicase DNA-binding domain [46819] (2 proteins)
    follows the extended AAA-ATPase domain
  12. 351756a.4.5.12: Restriction endonuclease FokI, N-terminal (recognition) domain [46824] (1 protein)
  13. 351768a.4.5.13: Linker histone H1/H5 [46827] (3 proteins)
  14. 351781a.4.5.14: Forkhead DNA-binding domain [46832] (5 proteins)
  15. 351798a.4.5.15: DNA-binding domain from rap30 [46841] (1 protein)
  16. 351803a.4.5.16: C-terminal domain of RPA32 [46844] (1 protein)
  17. 351807a.4.5.17: Cell cycle transcription factor e2f-dp [46847] (2 proteins)
    heterodimer of two homologous chains
  18. 351814a.4.5.18: The central core domain of TFIIE beta [46850] (1 protein)
  19. 351819a.4.5.19: Z-DNA binding domain [46853] (3 proteins)
  20. 351832a.4.5.20: P4 origin-binding domain-like [46856] (2 proteins)
    C-terminus passes through the first loop
  21. 351844a.4.5.21: ets domain [46859] (6 proteins)
  22. 351884a.4.5.22: Heat-shock transcription factor [46873] (1 protein)
  23. 351904a.4.5.23: Interferon regulatory factor [46877] (2 proteins)
  24. 351919a.4.5.24: Iron-dependent repressor protein [46882] (3 proteins)
  25. 351963a.4.5.25: Methionine aminopeptidase, insert domain [46887] (1 protein)
    circularly permuted version of the "winged helix" fold
  26. 351981a.4.5.27: TnsA endonuclease, C-terminal domain [46782] (1 protein)
  27. 351986a.4.5.28: MarR-like transcriptional regulators [63379] (8 proteins)
    The N- and C-terminal helical extensions to the common fold form the dimer interface
  28. 352023a.4.5.29: Plant O-methyltransferase, N-terminal domain [63475] (4 proteins)
    unknown function
  29. 352044a.4.5.30: C-terminal domain of the rap74 subunit of TFIIF [63480] (1 protein)
  30. 352051a.4.5.31: DEP domain [63483] (4 proteins)
    membrane-binding domain
  31. 352064a.4.5.32: Lrp/AsnC-like transcriptional regulator N-terminal domain [68967] (2 proteins)
    Swapped dimer with the "wing" C-terminal strands
  32. 352072a.4.5.33: Transcriptional regulator IclR, N-terminal domain [74676] (1 protein)
  33. 352077a.4.5.34: SCF ubiquitin ligase complex WHB domain [74679] (2 proteins)
  34. 352090a.4.5.35: C-terminal fragment of elongation factor SelB [74683] (1 protein)
  35. 352097a.4.5.36: DNA-binding protein Mj223 [81690] (1 protein)
    homologous to the MarR-like family in the DNA-binding region but dimerizes differently through the N- and C-terminal helical extensions to the common fold
  36. 352102a.4.5.37: LysR-like transcriptional regulators [88979] (1 protein)
    contains long helix in the C-terminal extension; forms dimer similar to the RTP dimer
  37. 352111a.4.5.38: AT-rich DNA-binding protein p25, N-terminal domain [101007] (1 protein)
  38. 352121a.4.5.39: Penicillinase repressor [101016] (2 proteins)
    homologous to the MarR-like family in the DNA-binding region but has a different dimerisation subdomain
  39. 352135a.4.5.40: N-terminal domain of Bacillus PurR [101021] (1 protein)
  40. 352146a.4.5.41: Transcription factor E/IIe-alpha, N-terminal domain [101024] (1 protein)
    contains extra N-terminal helix
  41. 352150a.4.5.42: FUR-like [101027] (1 protein)
    contains extra N-terminal helix and an alpha+beta dimerisation subdomain
  42. 352154a.4.5.43: DNA helicase RecQ DNA-binding domain [101030] (1 protein)
    follows the tandem AAA-ATPase domain
  43. 352159a.4.5.44: 39 kda initiator binding protein, IBP39, N-terminal domain [101045] (1 protein)
  44. 352169a.4.5.45: Dissimilatory sulfite reductase DsvD [101048] (1 protein)
  45. 352174a.4.5.46: La domain [101051] (1 protein)
    Pfam 05383; RNA-binding domain

More info for Superfamily a.4.5: "Winged helix" DNA-binding domain

Timeline for Superfamily a.4.5: "Winged helix" DNA-binding domain: