SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family a.1.1.2: Globins

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1976410Fold a.1: Globin-like [46457] (2 superfamilies)
    core: 6 helices; folded leaf, partly opened
  4. 1976411Superfamily a.1.1: Globin-like [46458] (5 families) (S)
  5. 1976488Family a.1.1.2: Globins [46463] (27 protein domains)
    Heme-binding protein

Protein Domains:

  1. 1976489Ascaris hemoglobin, domain 1 [46520] (1 species)
  2. 1976492Bacterial dimeric hemoglobin [46526] (1 species)
  3. 1976506Chimeric hemoglobin beta-alpha [46516] (1 species)
  4. 1976512Cytoglobin [109626] (1 species)
  5. 1976528Dehaloperoxidase [46530] (1 species)
  6. 1976592Erythrocruorin [46479] (1 species)
  7. 1976598Extracellular dodecameric hemoglobin (erythrocruorin), subunit D1 [116758] (1 species)
  8. 1976606Extracellular dodecameric hemoglobin (erythrocruorin), subunit II (globin B) [116754] (1 species)
  9. 1976614Extracellular dodecameric hemoglobin (erythrocruorin), subunit III (globin C) [116756] (1 species)
  10. 1976622Extracellular dodecameric hemoglobin (erythrocruorin), subunit IV (globin A) [116752] (1 species)
  11. 1976630Flavohemoglobin, N-terminal domain [46528] (2 species)
    1. 1976631Species Alcaligenes eutrophus [TaxId:106590] [46529] (1 PDB entry)
    2. 1976634Species Escherichia coli [TaxId:562] [74663] (1 PDB entry)
  12. 1976636Glycera globin [46467] (1 species)
  13. 1976646Hagfish hemoglobin [68941] (1 species)
  14. 1976654Heme-based aerotactic transducer HemAT, sensor domain [100980] (1 species)
  15. 1976660Hemoglobin [46522] (1 species)
  16. 1976664Hemoglobin I [46464] (2 species)
    1. 1976665Species Ark clam (Scapharca inaequivalvis) [TaxId:6561] [46465] (37 PDB entries)
    2. 1976754Species Clam (Lucina pectinata) [TaxId:244486] [46466] (4 PDB entries)
  17. 1976759Hemoglobin, alpha-chain [46486] (24 species)
    1. 1976760Species Aldabra giant tortoise (Geochelone gigantea) [TaxId:167804] [100976] (3 PDB entries)
      Uniprot P83134
    2. 1976764Species Antarctic fish (Trematomus newnesi) [TaxId:35730] [46497] (6 PDB entries)
    3. 1976774Species Bar-headed goose (Anser indicus) [TaxId:8846] [46493] (4 PDB entries)
    4. 1976782Species Bluefin tuna (Thunnus thynnus) [TaxId:8237] [109623] (3 PDB entries)
      Uniprot Q8AYM0
    5. 1976789Species Cartilaginous fish akaei (Dasyatis akajei) [TaxId:31902] [46496] (2 PDB entries)
    6. 1976792Species Chicken (Gallus gallus) [TaxId:9031] [46492] (1 PDB entry)
    7. 1976795Species Cow (Bos taurus) [TaxId:9913] [46490] (11 PDB entries)
    8. 1976818Species Deer (Odocoileus virginianus) [TaxId:9874] [46489] (1 PDB entry)
    9. 1976821Species Dog (Canis familiaris) [TaxId:9615] [189534] (3 PDB entries)
    10. 1976826Species Donkey (Equus asinus) [TaxId:9793] [158217] (1 PDB entry)
      Uniprot P01959 1-141
      beta-chain sequences of donkey and horse hemoglobins are identical
    11. 1976828Species Dusicyon thous [TaxId:9620] [186966] (1 PDB entry)
    12. 1976832Species Emerald rockcod (Pagothenia bernacchii) [TaxId:40690] [46495] (12 PDB entries)
    13. 1976852Species Fish (Leiostomus xanthurus) [TaxId:59837] [46498] (1 PDB entry)
    14. 1976854Species Graylag goose (Anser anser) [TaxId:8843] [68938] (1 PDB entry)
    15. 1976857Species Horse (Equus caballus) [TaxId:9796] [46488] (17 PDB entries)
    16. 1976879Species Houndshark (Mustelus griseus) [TaxId:89020] [46499] (2 PDB entries)
    17. 1976884Species Human (Homo sapiens) [TaxId:9606] [46487] (247 PDB entries)
      Uniprot P69905 P01922 P01934 P01935
    18. 1977358Species Human (Homo sapiens), zeta isoform [TaxId:9606] [68937] (2 PDB entries)
    19. 1977364Species Maned wolf (Chrysocyon brachyurus) [TaxId:68728] [63440] (1 PDB entry)
    20. 1977367Species Peromyscus maniculatus [TaxId:10042] [224840] (1 PDB entry)
    21. 1977369Species Pig (Sus scrofa) [TaxId:9823] [46491] (3 PDB entries)
    22. 1977378Species Rainbow trout (Oncorhynchus mykiss) [TaxId:8022] [46494] (2 PDB entries)
    23. 1977382Species Yellow perch (Perca flavescens) [TaxId:8167] [116749] (1 PDB entry)
      Uniprot P83270; 78% sequence identity
    24. 2283312Species Ochotona princeps [TaxId:9978] [326613] (1 PDB entry)
  18. 1977385Hemoglobin, beta-chain [46500] (25 species)
    1. 1977386Species Aldabra giant tortoise (Geochelone gigantea) [TaxId:167804] [100977] (3 PDB entries)
      Uniprot P83133
    2. 1977390Species Antarctic fish (Trematomus newnesi) [TaxId:35730] [46513] (6 PDB entries)
    3. 1977400Species Bar-headed goose (Anser indicus) [TaxId:8846] [46509] (4 PDB entries)
    4. 1977408Species Bluefin tuna (Thunnus thynnus) [TaxId:8237] [109624] (3 PDB entries)
      Uniprot Q8AYM1
    5. 1977415Species Canis lupus [TaxId:9615] [311319] (1 PDB entry)
    6. 1977417Species Cartilaginous fish akaei (Dasyatis akajei) [TaxId:31902] [46512] (2 PDB entries)
    7. 1977420Species Chicken (Gallus gallus) [TaxId:9031] [46508] (1 PDB entry)
    8. 1977423Species Cow (Bos taurus) [TaxId:9913] [46506] (11 PDB entries)
    9. 1977446Species Deer (Odocoileus virginianus) [TaxId:9874] [46505] (1 PDB entry)
    10. 1977449Species Dog (Canis familiaris) [TaxId:9615] [158218] (3 PDB entries)
    11. 1977455Species Donkey (Equus asinus) [TaxId:9793] [158216] (1 PDB entry)
      beta-chain sequences of donkey and horse hemoglobins are identical
    12. 1977457Species Emerald rockcod (Pagothenia bernacchii) [TaxId:40690] [46511] (12 PDB entries)
    13. 1977477Species Fish (Leiostomus xanthurus) [TaxId:59837] [46514] (1 PDB entry)
    14. 1977479Species Graylag goose (Anser anser) [TaxId:8843] [68940] (1 PDB entry)
    15. 1977482Species Horse (Equus caballus) [TaxId:9796] [46504] (17 PDB entries)
    16. 1977504Species Houndshark (Mustelus griseus) [TaxId:89020] [46515] (2 PDB entries)
    17. 1977509Species Human (Homo sapiens) [TaxId:9606] [46501] (239 PDB entries)
      Uniprot P68871
    18. 1977968Species Human (Homo sapiens), delta-chain [TaxId:9606] [116750] (2 PDB entries)
      Uniprot P02042
    19. 1977973Species Human (Homo sapiens), embryonic gower II [TaxId:9606] [46503] (1 PDB entry)
    20. 1977976Species Human fetus (Homo sapiens), gamma-chain [TaxId:9606] [46502] (3 PDB entries)
    21. 1977983Species Maned wolf (Chrysocyon brachyurus) [TaxId:68728] [63441] (1 PDB entry)
    22. 1977986Species Mouse (Mus musculus) [TaxId:10090] [68939] (1 PDB entry)
    23. 1977989Species Pig (Sus scrofa) [TaxId:9823] [46507] (3 PDB entries)
    24. 1977998Species Rainbow trout (Oncorhynchus mykiss) [TaxId:8022] [46510] (2 PDB entries)
    25. 1978002Species Yellow perch (Perca flavescens) [TaxId:8167] [116751] (4 PDB entries)
      Uniprot P83273; 86% sequence identity
  19. 1978011Hemoglobin, different isoforms [46524] (1 species)
  20. 1978015Hypothetical protein PA3967 [109628] (1 species)
  21. 1978018Lamprey globin [46518] (2 species)
    1. 1978019Species Lamprey (Lampetra fluviatilis) [TaxId:7748] [88966] (1 PDB entry)
    2. 1978032Species Sea lamprey (Petromyzon marinus) [TaxId:7757] [46519] (4 PDB entries)
  22. 1978058Leghemoglobin [46481] (2 species)
    1. 1978059Species Soybean (Glycine max), isoform A [TaxId:3847] [46483] (2 PDB entries)
    2. 1978064Species Yellow lupine (Lupinus luteus) [TaxId:3873] [46482] (17 PDB entries)
  23. 1978082Myoglobin [46469] (9 species)
    1. 1978083Species Asian elephant (Elephas maximus) [TaxId:9783] [46476] (1 PDB entry)
    2. 1978085Species Common seal (Phoca vitulina) [TaxId:9720] [46472] (1 PDB entry)
    3. 1978087Species Horse (Equus caballus) [TaxId:9796] [46474] (84 PDB entries)
    4. 1978173Species Human (Homo sapiens) [TaxId:9606] [46475] (1 PDB entry)
    5. 1978175Species Loggerhead sea turtle (Caretta caretta) [TaxId:8467] [46477] (2 PDB entries)
    6. 1978178Species Pig (Sus scrofa) [TaxId:9823] [46473] (17 PDB entries)
    7. 1978212Species Slug sea hare (Aplysia limacina) [TaxId:6502] [46471] (7 PDB entries)
    8. 1978220Species Sperm whale (Physeter catodon) [TaxId:9755] [46470] (261 PDB entries)
      Uniprot P02185
    9. 1978469Species Yellowfin tuna (Thunnus albacares) [TaxId:8236] [46478] (1 PDB entry)
  24. 1978471Neuroglobin [100978] (2 species)
    1. 1978472Species Human (Homo sapiens) [TaxId:9606] [100979] (2 PDB entries)
    2. 1978479Species Mouse (Mus musculus) [TaxId:10090] [109625] (21 PDB entries)
      Uniprot Q9ER97
  25. 1978492Non-symbiotic plant hemoglobin [46484] (1 species)
  26. 1978500Trematode hemoglobin/myoglobin [63438] (1 species)
  27. 1978505automated matches [190359] (41 species)
    not a true protein
    1. 1978506Species Amphitrite ornata [TaxId:129555] [189339] (5 PDB entries)
    2. 1978513Species Ark clam (Scapharca inaequivalvis) [TaxId:6561] [187427] (32 PDB entries)
    3. 1978586Species Barley (Hordeum vulgare) [TaxId:4513] [187359] (1 PDB entry)
    4. 1978595Species Brycon cephalus [TaxId:126311] [188621] (1 PDB entry)
    5. 1978600Species Buffalo (Bubalus bubalis) [TaxId:89462] [188864] (1 PDB entry)
    6. 1978605Species Camel (Camelus dromedarius) [TaxId:9838] [189249] (1 PDB entry)
    7. 1978610Species Cat (Felis catus) [TaxId:9685] [188888] (4 PDB entries)
    8. 1978635Species Coturnix japonica [TaxId:93934] [189557] (1 PDB entry)
    9. 1978640Species Domestic pigeon (Columba livia) [TaxId:8932] [188616] (2 PDB entries)
    10. 1978653Species Dromaius novaehollandiae [TaxId:8790] [258618] (1 PDB entry)
    11. 1978658Species Duck (Anas platyrhynchos) [TaxId:8839] [189063] (1 PDB entry)
    12. 1978661Species Dusicyon thous [TaxId:9620] [187446] (1 PDB entry)
    13. 1978663Species Eleginops maclovinus [TaxId:56733] [193401] (1 PDB entry)
    14. 1978668Species Escherichia coli [TaxId:562] [196657] (1 PDB entry)
    15. 1978671Species Glossoscolex paulistus [TaxId:1046353] [273742] (1 PDB entry)
    16. 1978673Species Goat (Capra hircus) [TaxId:9925] [188635] (3 PDB entries)
    17. 1978690Species Guinea pig (Cavia porcellus) [TaxId:10141] [189281] (2 PDB entries)
    18. 1978695Species Helogale parvula [TaxId:210647] [277372] (2 PDB entries)
    19. 1978702Species Human (Homo sapiens) [TaxId:9606] [188371] (6 PDB entries)
    20. 1978720Species Isurus oxyrinchus [TaxId:57983] [189618] (1 PDB entry)
    21. 1978725Species Lepus europaeus [TaxId:9983] [189630] (1 PDB entry)
    22. 1978730Species Maize (Zea mays) [TaxId:76912] [188014] (1 PDB entry)
    23. 1978735Species Mammuthus primigenius [TaxId:37349] [194337] (3 PDB entries)
    24. 1978744Species Mouse (Mus musculus) [TaxId:10090] [187190] (2 PDB entries)
    25. 1978750Species Norway rat (Rattus norvegicus) [TaxId:10116] [188924] (2 PDB entries)
    26. 1978757Species Parasponia andersonii [TaxId:3476] [193708] (1 PDB entry)
    27. 1978760Species Peromyscus maniculatus [TaxId:10042] [196779] (2 PDB entries)
    28. 1978762Species Podocnemis unifilis [TaxId:227871] [189922] (2 PDB entries)
    29. 1978767Species Psittacula krameri [TaxId:9228] [255724] (1 PDB entry)
    30. 1978770Species Pteropus giganteus [TaxId:143291] [188768] (1 PDB entry)
    31. 1978773Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [188592] (1 PDB entry)
    32. 1978778Species Rainbow trout (Oncorhynchus mykiss) [TaxId:8022] [188309] (2 PDB entries)
    33. 1978787Species Sheep (Ovis aries) [TaxId:9940] [188522] (1 PDB entry)
    34. 1978792Species Sperm whale (Physeter catodon) [TaxId:9755] [188226] (4 PDB entries)
    35. 1978797Species Struthio camelus [TaxId:8801] [188835] (1 PDB entry)
    36. 1978802Species Thunnus atlanticus [TaxId:48168] [187921] (8 PDB entries)
    37. 1978811Species Thunnus orientalis [TaxId:8238] [187933] (1 PDB entry)
    38. 1978813Species Trema tomentosa [TaxId:3480] [196352] (1 PDB entry)
    39. 1978816Species Turkey (Meleagris gallopavo) [TaxId:9103] [189160] (2 PDB entries)
    40. 1978825Species Yellow perch (Perca flavescens) [TaxId:8167] [188574] (3 PDB entries)
    41. 2283315Species Ochotona princeps [TaxId:9978] [326616] (1 PDB entry)

More info for Family a.1.1.2: Globins

Timeline for Family a.1.1.2: Globins: