SCOPe 2.06: Domain d4hira_: 4hir A:

Lineage for d4hira_ (4hir A:)

1. Root: SCOPe 2.06

2. Class g: Small proteins [56992] (94 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.15: Leech antihemostatic proteins [57262] (3 families)

5. Family g.3.15.2: Hirudin-like [57270] (4 proteins)

6. Protein Hirudin [57271] (1 species)

7. Species Medicinal leech (Hirudo medicinalis) [TaxId:6421] [57272] (9 PDB entries)

8. Domain d4hira_: 4hir A: [44374]
   mutant

Details for d4hira_

PDB Entry: 4hir

PDB Description: solution structure of recombinant hirudin and the lys-47 (right arrow) glu mutant. a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study

PDB Compounds: (A:) hirudin variant-1

SCOPe Domain Sequences for d4hira_:

Sequence; same for both SEQRES and ATOM records:

>d4hira_ g.3.15.2 (A:) Hirudin {Medicinal leech (Hirudo medicinalis) [TaxId: 6421]}
vvytdctesgqnlclcegsnvcgqgnkcilgsdgeknqcvtgegtpepq

Timeline for d4hira_:

• d4hira_ first appeared (with stable ids) in SCOP 1.55, called d4hir__
  
• d4hira_ appears in SCOPe 2.05
  
• d4hira_ appears in SCOPe 2.07
  
• d4hira_ appears in the current release, SCOPe 2.08