SCOP 1.75: Domain d1fkpb_: 1fkp B:

Lineage for d1fkpb_ (1fkp B:)

1. Root: SCOP 1.75

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (111 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582
   Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584
   Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d1fkpb_: 1fkp B: [43099]
   Other proteins in same PDB: d1fkpa1
   complexed with nvp; mutant

Details for d1fkpb_

PDB Entry: 1fkp, 2.9 Å

PDB Description: crystal structure of nnrti resistant k103n mutant hiv-1 reverse transcriptase in complex with nevirapine

PDB Compounds: (B:) hiv-1 rt, b-chain

SCOP Domain Sequences for d1fkpb_:

Sequence, based on SEQRES records:

>d1fkpb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsvpldedf
rkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqym
ddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpi
vlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelela
enreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtnd
vkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvk
lwyqlekepivgae

Sequence, based on observed residues (ATOM records):

>d1fkpb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfphpaglkknksvtvldvgdayfsvpldedfrkytaft
ipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgs
dleigqhrtkieelrqhllrwgelhpdkwtvqpivlpekdswtvndiqklvgklnwasqi
ypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiq
kqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkfk
lpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgae

Timeline for d1fkpb_:

• d1fkpb_ first appeared (with stable ids) in SCOP 1.55, called d1fkpb1
  
• d1fkpb_ appears in SCOP 1.73
  
• d1fkpb_ appears in SCOPe 2.01
  
• d1fkpb_ appears in the current release, SCOPe 2.08