SCOP 1.69: Domain d1ep4b_: 1ep4 B:

Lineage for d1ep4b_ (1ep4 B:)

1. Root: SCOP 1.69

2. Class e: Multi-domain proteins (alpha and beta) [56572] (46 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (78 PDB entries)

8. Domain d1ep4b_: 1ep4 B: [43093]
   Other proteins in same PDB: d1ep4a1

Details for d1ep4b_

PDB Entry: 1ep4, 2.5 Å

PDB Description: Crystal structure of HIV-1 reverse transcriptase in complex with S-1153

SCOP Domain Sequences for d1ep4b_:

Sequence, based on SEQRES records:

>d1ep4b_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedf
rkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqym
ddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpi
vlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelela
enreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtnd
vkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvk
lwy

Sequence, based on observed residues (ATOM records):

>d1ep4b_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwhpaglkkkksvtvldvgdayfsvpldedfrkytaft
ipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgs
dleigqhrtkieelrqhllrwgltyelhpdkwtvqpivlpekdswtvndiqklvgklnwa
sqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdlia
eiqkqgqgqwtyqiyqepfknlktgkyartndvkqlteavqkittesiviwgktpkfklp
iqketwetwwteywqatwipewefvntpplvklwy

Timeline for d1ep4b_:

• d1ep4b_ first appeared (with stable ids) in SCOP 1.55, called d1ep4b1
  
• d1ep4b_ appears in SCOP 1.67
  
• d1ep4b_ appears in SCOP 1.71
  
• d1ep4b_ appears in the current release, SCOPe 2.08