SCOP 1.63: Domain d1ep4a2: 1ep4 A:4-429

Lineage for d1ep4a2 (1ep4 A:4-429)

1. Root: SCOP 1.63

2. Class e: Multi-domain proteins (alpha and beta) [56572] (39 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (63 PDB entries)

8. Domain d1ep4a2: 1ep4 A:4-429 [43092]
   Other proteins in same PDB: d1ep4a1
   complexed with s11

Details for d1ep4a2

PDB Entry: 1ep4, 2.5 Å

PDB Description: Crystal structure of HIV-1 reverse transcriptase in complex with S-1153

SCOP Domain Sequences for d1ep4a2:

Sequence, based on SEQRES records:

>d1ep4a2 e.8.1.2 (A:4-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplded
frkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqy
mddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqp
ivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelel
aenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtn
dvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplv
klwyql

Sequence, based on observed residues (ATOM records):

>d1ep4a2 e.8.1.2 (A:4-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkyta
ftipsiniryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgsdle
igqhrtkieelrqhllrwglttpdhqkeppflwmgyelhpdkwtvqpivlpekdswtvnd
iqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhg
vyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkit
tesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql

Timeline for d1ep4a2:

• d1ep4a2 first appeared (with stable ids) in SCOP 1.55
  
• d1ep4a2 appears in SCOP 1.61
  
• d1ep4a2 appears in SCOP 1.65
  
• d1ep4a2 appears in the current release, SCOPe 2.08