SCOPe 2.04: Domain d1ivha2: 1ivh A:6-241

Lineage for d1ivha2 (1ivh A:6-241)

1. Root: SCOPe 2.04

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.6: Acyl-CoA dehydrogenase NM domain-like [56644] (1 superfamily)
   2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology

4. Superfamily e.6.1: Acyl-CoA dehydrogenase NM domain-like [56645] (3 families)
   flavoprotein: binds FAD; constituent families differ in the numbers of C-terminal domains (four-helical bundles)

5. Family e.6.1.1: Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains [56646] (10 proteins)

6. Protein Isovaleryl-coa dehydrogenase, NM domains [56652] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56653] (1 PDB entry)

8. Domain d1ivha2: 1ivh A:6-241 [42869]
   Other proteins in same PDB: d1ivha1, d1ivhb1, d1ivhc1, d1ivhd1
   complexed with cos, fad

Details for d1ivha2

PDB Entry: 1ivh, 2.6 Å

PDB Description: structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity

PDB Compounds: (A:) isovaleryl-coa dehydrogenase

SCOPe Domain Sequences for d1ivha2:

Sequence; same for both SEQRES and ATOM records:

>d1ivha2 e.6.1.1 (A:6-241) Isovaleryl-coa dehydrogenase, NM domains {Human (Homo sapiens) [TaxId: 9606]}
vddainglseeqrqlrqtmakflqehlapkaqeidrsnefknlrefwkqlgnlgvlgita
pvqyggsglgylehvlvmeeisrasgavglsygahsnlcinqlvrngneaqkekylpkli
sgeyigalamsepnagsdvvsmklkaekkgnhyilngnkfwitngpdadvlivyaktdla
avpasrgitafivekgmpgfstskkldklgmrgsntcelifedckipaanilghen

Timeline for d1ivha2:

• d1ivha2 first appeared (with stable ids) in SCOP 1.55
  
• d1ivha2 appears in SCOPe 2.03
  
• d1ivha2 appears in SCOPe 2.05
  
• d1ivha2 appears in the current release, SCOPe 2.08