SCOPe 2.08: Domain d7efpa_: 7efp A:

Lineage for d7efpa_ (7efp A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ('zincins'), catalytic domain [55486] (18 families)

5. Family d.92.1.5: Neurolysin-like [55505] (5 proteins)
   combines M2, M3 and M32 families of metalloproteases
   the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

6. Protein Angiotensin converting enzyme 2, ACE2 [103125] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [103126] (34 PDB entries)

8. Domain d7efpa_: 7efp A: [421668]
   Other proteins in same PDB: d7efpb_
   automated match to d3scia_
   complexed with nag; mutant

Details for d7efpa_

PDB Entry: 7efp, 2.7 Å

PDB Description: structure of sars-cov-2 spike receptor-binding domain in complex with high affinity ace2 mutant (s19w,n330y)

PDB Compounds: (A:) Processed angiotensin-converting enzyme 2

SCOPe Domain Sequences for d7efpa_:

Sequence; same for both SEQRES and ATOM records:

>d7efpa_ d.92.1.5 (A:) Angiotensin converting enzyme 2, ACE2 {Human (Homo sapiens) [TaxId: 9606]}
wtieeqaktfldkfnheaedlfyqsslaswnyntniteenvqnmnnagdkwsaflkeqst
laqmyplqeiqnltvklqlqalqqngssvlsedkskrlntilntmstiystgkvcnpdnp
qeclllepglneimansldynerlwaweswrsevgkqlrplyeeyvvlknemaranhyed
ygdywrgdyevngvdgydysrgqliedvehtfeeikplyehlhayvraklmnaypsyisp
igclpahllgdmwgrfwtnlysltvpfgqkpnidvtdamvdqawdaqrifkeaekffvsv
glpnmtqgfweysmltdpgnvqkavchptawdlgkgdfrilmctkvtmddfltahhemgh
iqydmayaaqpfllrnganegfheavgeimslsaatpkhlksigllspdfqedneteinf
llkqaltivgtlpftymlekwrwmvfkgeipkdqwmkkwwemkreivgvvepvphdetyc
dpaslfhvsndysfiryytrtlyqfqfqealcqaakhegplhkcdisnsteagqklfnml
rlgksepwtlalenvvgaknmnvrpllnyfeplftwlkdqnknsfvgwstdwspya

Timeline for d7efpa_:

• d7efpa_ is new in SCOPe 2.08-stable