SCOPe 2.08: Domain d1hyhd2: 1hyh D:167-329

Lineage for d1hyhd2 (1hyh D:167-329)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
   automatically mapped to Pfam PF02866

6. Protein L-2-hydroxyisocapronate dehydrogenase, L-HICDH [56337] (1 species)

7. Species Lactobacillus confusus [TaxId:1583] [56338] (1 PDB entry)

8. Domain d1hyhd2: 1hyh D:167-329 [42120]
   Other proteins in same PDB: d1hyha1, d1hyhb1, d1hyhc1, d1hyhd1
   complexed with nad, so4

Details for d1hyhd2

PDB Entry: 1hyh, 2.2 Å

PDB Description: crystal structure of l-2-hydroxyisocaproate dehydrogenase from lactobacillus confusus at 2.2 angstroms resolution-an example of strong asymmetry between subunits

PDB Compounds: (D:) l-2-hydroxyisocaproate dehydrogenase

SCOPe Domain Sequences for d1hyhd2:

Sequence, based on SEQRES records:

>d1hyhd2 d.162.1.1 (D:167-329) L-2-hydroxyisocapronate dehydrogenase, L-HICDH {Lactobacillus confusus [TaxId: 1583]}
gtlldtarmqravgeafdldprsvsgynlgehgnsqfvawstvrvmgqpivtladagdid
laaieeearkggftvlngkgytsygvatsairiakavmadahaelvvsnrrddmgmylsy
paiigrdgvlaettldlttdeqekllqsrdyiqqrfdeivdtl

Sequence, based on observed residues (ATOM records):

>d1hyhd2 d.162.1.1 (D:167-329) L-2-hydroxyisocapronate dehydrogenase, L-HICDH {Lactobacillus confusus [TaxId: 1583]}
gtlldtarmqravgeafdldprsvsgynlgehgnsqfvawstvrvmgqpivtladaidla
aieeearkggftvlngkgytsygvatsairiakavmadahaelvvsnrrddmgmylsypa
iigrdgvlaettldlttdeqekllqsrdyiqqrfdeivdtl

Timeline for d1hyhd2:

• d1hyhd2 first appeared (with stable ids) in SCOP 1.55
  
• d1hyhd2 appears in SCOPe 2.07