SCOPe 2.08: Domain d7b7sa_: 7b7s A:

Lineage for d7b7sa_ (7b7s A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d7b7sa_: 7b7s A: [420713]
   Other proteins in same PDB: d7b7sb1, d7b7sb2, d7b7sd1, d7b7sd2
   automated match to d6q49a_
   complexed with no3, sgm, so4, t1t

Details for d7b7sa_

PDB Entry: 7b7s, 2.54 Å

PDB Description: cdk2/cyclin a2 in complex with 3h-pyrazolo[4,3-f]quinoline-based derivative hsd1368

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d7b7sa_:

Sequence, based on SEQRES records:

>d7b7sa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpv

Sequence, based on observed residues (ATOM records):

>d7b7sa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtvvykarnkltgevvalkkirldtegvpstaireisllkelnhpniv
klldvihnklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhr
dlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystavdi
wslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarq
dfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpv

Timeline for d7b7sa_:

• d7b7sa_ is new in SCOPe 2.08-stable