Lineage for d2fgib_ (2fgi B:)

  1. Root: SCOPe 2.02
  2. 1190016Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1220003Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1220004Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1220070Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1220746Protein Fibroblast growth factor receptor 1 [56158] (1 species)
    PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase
  7. 1220747Species Human (Homo sapiens) [TaxId:9606] [56159] (9 PDB entries)
  8. 1220761Domain d2fgib_: 2fgi B: [41700]
    complexed with pd1

Details for d2fgib_

PDB Entry: 2fgi (more details), 2.5 Å

PDB Description: crystal structure of the tyrosine kinase domain of fgf receptor 1 in complex with inhibitor pd173074
PDB Compounds: (B:) protein (fibroblast growth factor (fgf) receptor 1)

SCOPe Domain Sequences for d2fgib_:

Sequence, based on SEQRES records: (download)

>d2fgib_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksda
tekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppg
leysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkia
dfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggsp
ypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrival
t

Sequence, based on observed residues (ATOM records): (download)

>d2fgib_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaiglpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrqlsskdl
vscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgladyykkgrlpvkwmap
ealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctnel
ymmmrdcwhavpsqrptfkqlvedldrivalt

SCOPe Domain Coordinates for d2fgib_:

Click to download the PDB-style file with coordinates for d2fgib_.
(The format of our PDB-style files is described here.)

Timeline for d2fgib_: