SCOP 1.63: Domain d1fgib_: 1fgi B:

Lineage for d1fgib_ (1fgi B:)

1. Root: SCOP 1.63

2. Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (6 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.2: Tyrosine kinase [56150] (15 proteins)

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (4 PDB entries)

8. Domain d1fgib_: 1fgi B: [41698]
   complexed with su1; mutant

Details for d1fgib_

PDB Entry: 1fgi, 2.5 Å

PDB Description: crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in complex with su5402 inhibitor

SCOP Domain Sequences for d1fgib_:

Sequence, based on SEQRES records:

>d1fgib_ d.144.1.2 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens)}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksda
tekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppg
leysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkia
dfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggsp
ypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrival
t

Sequence, based on observed residues (ATOM records):

>d1fgib_ d.144.1.2 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens)}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaiglpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrqlsskdl
vscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgladyykkgrlpvkwmap
ealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctnel
ymmmrdcwhavpsqrptfkqlvedldrivalt

Timeline for d1fgib_:

• d1fgib_ first appeared (with stable ids) in SCOP 1.55
  
• d1fgib_ appears in SCOP 1.61
  
• d1fgib_ appears in SCOP 1.65
  
• d1fgib_ appears in the current release, SCOPe 2.08