SCOP 1.63: Domain d1agwb_: 1agw B:

Lineage for d1agwb_ (1agw B:)

1. Root: SCOP 1.63

2. Class d: Alpha and beta proteins (a+b) [53931] (224 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (6 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.2: Tyrosine kinase [56150] (15 proteins)

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (4 PDB entries)

8. Domain d1agwb_: 1agw B: [41696]
   complexed with su2; mutant

Details for d1agwb_

PDB Entry: 1agw, 2.4 Å

PDB Description: crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 in complex with su4984 inhibitor

SCOP Domain Sequences for d1agwb_:

Sequence, based on SEQRES records:

>d1agwb_ d.144.1.2 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens)}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksda
tekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppg
leysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkia
dfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggsp
ypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrival
t

Sequence, based on observed residues (ATOM records):

>d1agwb_ d.144.1.2 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens)}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaiglpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrqlsskdl
vscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgladyykkgrlpvkwmap
ealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctnel
ymmmrdcwhavpsqrptfkqlvedldrivalt

Timeline for d1agwb_:

• d1agwb_ first appeared (with stable ids) in SCOP 1.55
  
• d1agwb_ appears in SCOP 1.61
  
• d1agwb_ appears in SCOP 1.65
  
• d1agwb_ appears in the current release, SCOPe 2.08