SCOP 1.65: Domain d1fgkb_: 1fgk B:

Lineage for d1fgkb_ (1fgk B:)

1. Root: SCOP 1.65

2. Class d: Alpha and beta proteins (a+b) [53931] (234 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (6 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (41 proteins)
   members organised in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (4 PDB entries)

8. Domain d1fgkb_: 1fgk B: [41694]
   mutant

Details for d1fgkb_

PDB Entry: 1fgk, 2 Å

PDB Description: crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1

SCOP Domain Sequences for d1fgkb_:

Sequence, based on SEQRES records:

>d1fgkb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens)}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksda
tekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppg
leysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkia
dfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggsp
ypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrival
t

Sequence, based on observed residues (ATOM records):

>d1fgkb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens)}
seyelpedprwelprdrlvlgkplgegafgqvvlaeaiglpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrqlsskdl
vscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgladyykkgrlpvkwmap
ealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctnel
ymmmrdcwhavpsqrptfkqlvedldrivalt

Timeline for d1fgkb_:

• d1fgkb_ first appeared (with stable ids) in SCOP 1.55
  
• d1fgkb_ appears in SCOP 1.63
  
• d1fgkb_ appears in SCOP 1.67
  
• d1fgkb_ appears in the current release, SCOPe 2.08