SCOP 1.73: Domain d1bi7a_: 1bi7 A:

Lineage for d1bi7a_ (1bi7 A:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK6 [88859] (1 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88860] (8 PDB entries)

8. Domain d1bi7a_: 1bi7 A: [41619]
   Other proteins in same PDB: d1bi7b_

Details for d1bi7a_

PDB Entry: 1bi7, 3.4 Å

PDB Description: mechanism of g1 cyclin dependent kinase inhibition from the structure of the cdk6-p16ink4a tumor suppressor complex

PDB Compounds: (A:) cyclin-dependent kinase 6

SCOP Domain Sequences for d1bi7a_:

Sequence, based on SEQRES records:

>d1bi7a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
dqqyecvaeigegaygkvfkardlknggrfvalkrvrvqtgeegmplstirevavlrhle
tfehpnvvrlfdvctvsrtdretkltlvfehvdqdlttyldkvpepgvptetikdmmfql
lrgldflhshrvvhrdlkpqnilvtssgqikladfglariysfqmaltsvvvtlwyrape
vllqssyatpvdlwsvgcifaemfrrkplfrgssdvdqlgkildviglpgeedwprdval
prqafhsksaqpiekfvtdidelgkdlllkcltfnpakrisaysalshpyfq

Sequence, based on observed residues (ATOM records):

>d1bi7a_ d.144.1.7 (A:) Cyclin-dependent PK, CDK6 {Human (Homo sapiens) [TaxId: 9606]}
dqqyecvaeigegaygkvfkardlknggrfvalkrvrvqehpnvvrlfdvctvsrtdret
kltlvfehvdqdlttyldkvpepgvptetikdmmfqllrgldflhshrvvhrdlkpqnil
vtssgqikladfglariysfqmaltsvvvtlwyrapevllqssyatpvdlwsvgcifaem
frrkplfrgssdvdqlgkildviglpgeedwprdvalprqafhsksaqpiekfvtdidel
gkdlllkcltfnpakrisaysalshpyfq

Timeline for d1bi7a_:

• d1bi7a_ first appeared (with stable ids) in SCOP 1.55
  
• d1bi7a_ appears in SCOP 1.71
  
• d1bi7a_ appears in SCOP 1.75
  
• d1bi7a_ appears in the current release, SCOPe 2.08