SCOPe 2.04: Domain d2shpa3: 2shp A:111-218

Lineage for d2shpa3 (2shp A:111-218)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein Tyrosine phoshatase shp-2 [55589] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55590] (1 PDB entry)

8. Domain d2shpa3: 2shp A:111-218 [40534]
   Other proteins in same PDB: d2shpa1, d2shpb1
   complexed with cat

Details for d2shpa3

PDB Entry: 2shp, 2 Å

PDB Description: tyrosine phosphatase shp-2

PDB Compounds: (A:) shp-2

SCOPe Domain Sequences for d2shpa3:

Sequence, based on SEQRES records:

>d2shpa3 d.93.1.1 (A:111-218) Tyrosine phoshatase shp-2 {Human (Homo sapiens) [TaxId: 9606]}
rwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthv
mircqelkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnt

Sequence, based on observed residues (ATOM records):

>d2shpa3 d.93.1.1 (A:111-218) Tyrosine phoshatase shp-2 {Human (Homo sapiens) [TaxId: 9606]}
rwfhghlsgkeaeklltekgkhgsflvresqshpgdfvlsvrtgdndgkskvthvmircq
elkydvgggerfdsltdlvehykknpmvetlgtvlqlkqplnt

Timeline for d2shpa3:

• d2shpa3 first appeared (with stable ids) in SCOP 1.55
  
• d2shpa3 appears in SCOPe 2.03
  
• d2shpa3 appears in SCOPe 2.05
  
• d2shpa3 appears in the current release, SCOPe 2.08