SCOPe 2.02: Domain d1qcfa2: 1qcf A:146-248

Lineage for d1qcfa2 (1qcf A:146-248)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

6. Protein Hemopoetic cell kinase Hck [55565] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55566] (4 PDB entries)

8. Domain d1qcfa2: 1qcf A:146-248 [40490]
   Other proteins in same PDB: d1qcfa1, d1qcfa3
   complexed with pp1

Details for d1qcfa2

PDB Entry: 1qcf, 2 Å

PDB Description: crystal structure of hck in complex with a src family-selective tyrosine kinase inhibitor

PDB Compounds: (A:) haematopoetic cell kinase (hck)

SCOPe Domain Sequences for d1qcfa2:

Sequence; same for both SEQRES and ATOM records:

>d1qcfa2 d.93.1.1 (A:146-248) Hemopoetic cell kinase Hck {Human (Homo sapiens) [TaxId: 9606]}
eewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvkhykir
tldnggfyisprstfstlqelvdhykkgndglcqklsvpcmss

Timeline for d1qcfa2:

• d1qcfa2 first appeared (with stable ids) in SCOP 1.55
  
• d1qcfa2 appears in SCOPe 2.01
  
• d1qcfa2 appears in SCOPe 2.03
  
• d1qcfa2 appears in the current release, SCOPe 2.08