Lineage for d7m0zb_ (7m0z B:)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2586062Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2586063Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2586210Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2587519Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
    OPK group (?); MAPKK subfamily; serine/threonine kinase
  7. 2587520Species Human (Homo sapiens) [TaxId:9606] [118138] (42 PDB entries)
    Uniprot Q02750 61-381
  8. 2587556Domain d7m0zb_: 7m0z B: [403554]
    Other proteins in same PDB: d7m0za_
    automated match to d5hzea_
    complexed with anp, chu, mg, so4

Details for d7m0zb_

PDB Entry: 7m0z (more details), 3.12 Å

PDB Description: crystal structure of the braf:mek1 kinases in complex with amppnp and ch5126766
PDB Compounds: (B:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d7m0zb_:

Sequence, based on SEQRES records: (download)

>d7m0zb_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
ldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihl
eikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagri
peqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidaman
afvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcqveg
daaetpprprtpgrplssygmdsrppmaifelldyivnepppklpsgvfslefqdfvnkc
liknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnq

Sequence, based on observed residues (ATOM records): (download)

>d7m0zb_ d.144.1.7 (B:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
ldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihl
eikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagri
peqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidaman
afvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmpmaifel
ldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfag
wlcstiglnq

SCOPe Domain Coordinates for d7m0zb_:

Click to download the PDB-style file with coordinates for d7m0zb_.
(The format of our PDB-style files is described here.)

Timeline for d7m0zb_: