SCOPe 2.08: Domain d7khhd1: 7khh D:44-168

Lineage for d7khhd1 (7khh D:44-168)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (15 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (1052 PDB entries)

8. Domain d7khhd1: 7khh D:44-168 [399273]
   Other proteins in same PDB: d7khha_, d7khhb_, d7khhc_, d7khhd2
   automated match to d6czua_
   complexed with wep

Details for d7khhd1

PDB Entry: 7khh, 2.28 Å

PDB Description: ternary complex of vhl/brd4-bd1/compound9 (4-(3,5-difluoropyridin-2- yl)-n-(11-(((s)-1-((2s,4r)-4-hydroxy-2-((4-(4-methylthiazol-5-yl) benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl) amino)-11-oxoundecyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3, 4,10,11-tetrahydro-1h-1,4,10-triazadibenzo[cd,f]azulene-6- carboxamide)

PDB Compounds: (D:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d7khhd1:

Sequence; same for both SEQRES and ATOM records:

>d7khhd1 a.29.2.0 (D:44-168) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiikt
pmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkine
lptee

Timeline for d7khhd1:

• d7khhd1 first appeared in SCOPe 2.07