SCOPe 2.08: Domain d7k7lb_: 7k7l B:

Lineage for d7k7lb_ (7k7l B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.69: 7-bladed beta-propeller [50964] (15 superfamilies)
   consists of seven 4-stranded beta-sheet motifs; meander

4. Superfamily b.69.4: WD40 repeat-like [50978] (4 families)
   also contains 8-bladed propellers

5. Family b.69.4.1: WD40-repeat [50979] (17 proteins)
   this is a repeat family; one repeat unit is 1tyq C:201-243 found in domain

6. Protein beta1-subunit of the signal-transducing G protein heterotrimer [50980] (1 species)

7. Species Cow (Bos taurus) [TaxId:9913] [50981] (73 PDB entries)

8. Domain d7k7lb_: 7k7l B: [394880]
   Other proteins in same PDB: d7k7la1, d7k7la2, d7k7la3, d7k7lg_
   automated match to d3v5wb_
   complexed with mg, w4d
   has additional insertions and/or extensions that are not grouped together

Details for d7k7lb_

PDB Entry: 7k7l, 2.54 Å

PDB Description: structure of a hit for g protein coupled receptor kinase 2 (grk2) inhibitor for the potential treatment of heart failure

PDB Compounds: (B:) Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

SCOPe Domain Sequences for d7k7lb_:

Sequence; same for both SEQRES and ATOM records:

>d7k7lb_ b.69.4.1 (B:) beta1-subunit of the signal-transducing G protein heterotrimer {Cow (Bos taurus) [TaxId: 9913]}
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

Timeline for d7k7lb_:

• d7k7lb_ first appeared in SCOPe 2.07