SCOPe 2.08: Domain d7a4bb_: 7a4b B:

Lineage for d7a4bb_ (7a4b B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Protein kinase CK2, alpha subunit [56142] (3 species)
   CMGC group; CK2 subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [75559] (184 PDB entries)

8. Domain d7a4bb_: 7a4b B: [394267]
   automated match to d3wara_
   complexed with gol, qxw, so4

Details for d7a4bb_

PDB Entry: 7a4b, 2.06 Å

PDB Description: crystal structure of human protein kinase ck2alpha (csnk2a1 gene product) in complex with the atp-competitive inhibitor 5,6-dibromo- 1h-triazolo[4,5-b]pyridine

PDB Compounds: (B:) Casein kinase II subunit alpha

SCOPe Domain Sequences for d7a4bb_:

Sequence; same for both SEQRES and ATOM records:

>d7a4bb_ d.144.1.7 (B:) Protein kinase CK2, alpha subunit {Human (Homo sapiens) [TaxId: 9606]}
sgpvpsrarvytdvnthrpreywdyeshvvewgnqddyqlvrklgrgkysevfeainitn
nekvvvkilkpvkkkkikreikilenlrggpniitladivkdpvsrtpalvfehvnntdf
kqlyqtltdydirfymyeilkaldychsmgimhrdvkphnvmidhehrklrlidwglaef
yhpgqeynvrvasryfkgpellvdyqmydysldmwslgcmlasmifrkepffhghdnydq
lvriakvlgtedlydyidkynieldprfndilgrhsrkrwerfvhsenqhlvspealdfl
dkllrydhqsrltareamehpyfytvvkdqar

Timeline for d7a4bb_:

• d7a4bb_ first appeared in SCOPe 2.07