Lineage for d6xrla1 (6xrl A:144-322)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2501110Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
    core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
  4. 2501111Superfamily d.15.1: Ubiquitin-like [54236] (11 families) (S)
  5. 2502429Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
    contains Pfam PF00788 and Pfam PF02196
  6. 2502449Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
    includes parts of the flanking linkers
  7. 2502450Species Human (Homo sapiens) [TaxId:9606] [54276] (77 PDB entries)
  8. 3093344Domain d6xrla1: 6xrl A:144-322 [393406]
    Other proteins in same PDB: d6xrla2, d6xrla3
    automated match to d1he8a3
    complexed with so4, v7y

Details for d6xrla1

PDB Entry: 6xrl (more details), 2.99 Å

PDB Description: crystal structure of human pi3k-gamma in complex with inhibitor ipi- 549
PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d6xrla1:

Sequence, based on SEQRES records: (download)

>d6xrla1 d.15.1.5 (A:144-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

Sequence, based on observed residues (ATOM records): (download)

>d6xrla1 d.15.1.5 (A:144-322) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkseqdfvlrvcgr
deylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee

SCOPe Domain Coordinates for d6xrla1:

Click to download the PDB-style file with coordinates for d6xrla1.
(The format of our PDB-style files is described here.)

Timeline for d6xrla1:

  • d6xrla1 is new in SCOPe 2.07-stable