SCOPe 2.08: Domain d6ut0c1: 6ut0 C:1-169

Lineage for d6ut0c1 (6ut0 C:1-169)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.8: G proteins [52592] (81 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

6. Protein automated matches [190047] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [186768] (291 PDB entries)

8. Domain d6ut0c1: 6ut0 C:1-169 [384422]
   Other proteins in same PDB: d6ut0b2, d6ut0c2, d6ut0d2
   automated match to d4lyhb_
   complexed with gdp, m1x, mg

Details for d6ut0c1

PDB Entry: 6ut0, 1.94 Å

PDB Description: identification of the clinical development candidate mrtx849, a covalent krasg12c inhibitor for the treatment of cancer

PDB Compounds: (C:) GTPase KRas

SCOPe Domain Sequences for d6ut0c1:

Sequence; same for both SEQRES and ATOM records:

>d6ut0c1 c.37.1.8 (C:1-169) automated matches {Human (Homo sapiens) [TaxId: 9606]}
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildtag
qeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

Timeline for d6ut0c1:

• d6ut0c1 first appeared in SCOPe 2.07