SCOP 1.75: Domain d1fkfa_: 1fkf A:

Lineage for d1fkfa_ (1fkf A:)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.26: FKBP-like [54533] (3 superfamilies)
   core: beta(2)-alpha-beta(2); antiparallel beta-sheet

4. Superfamily d.26.1: FKBP-like [54534] (3 families)

5. Family d.26.1.1: FKBP immunophilin/proline isomerase [54535] (16 proteins)

6. Protein FK-506 binding protein (FKBP12), an immunophilin [54536] (2 species)
   cis-trans prolyl-isomerase

7. Species Human (Homo sapiens) [TaxId:9606] [54537] (33 PDB entries)

8. Domain d1fkfa_: 1fkf A: [38386]
   complexed with fk5

Details for d1fkfa_

PDB Entry: 1fkf, 1.7 Å

PDB Description: atomic structure of fkbp-fk506, an immunophilin-immunosuppressant complex

PDB Compounds: (A:) fk506 binding protein

SCOP Domain Sequences for d1fkfa_:

Sequence; same for both SEQRES and ATOM records:

>d1fkfa_ d.26.1.1 (A:) FK-506 binding protein (FKBP12), an immunophilin {Human (Homo sapiens) [TaxId: 9606]}
gvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgwe
egvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle

Timeline for d1fkfa_:

• d1fkfa_ first appeared (with stable ids) in SCOP 1.55, called d1fkf__
  
• d1fkfa_ appears in SCOP 1.73
  
• d1fkfa_ appears in SCOPe 2.01
  
• d1fkfa_ appears in the current release, SCOPe 2.08