SCOPe 2.08: Domain d6spla_: 6spl A:

Lineage for d6spla_ (6spl A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Mouse (Mus musculus) [TaxId:10090] [56131] (111 PDB entries)

8. Domain d6spla_: 6spl A: [375252]
   automated match to d4aaca_
   complexed with ca, cl, low, sb4

Details for d6spla_

PDB Entry: 6spl, 1.38 Å

PDB Description: fragment kcl615 in complex with map kinase p38-alpha

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d6spla_:

Sequence, based on SEQRES records:

>d6spla_ d.144.1.7 (A:) MAP kinase p38 {Mouse (Mus musculus) [TaxId: 10090]}
ptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsiiha
krtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltdd
hvqfliyqilrglkyihsadiihrdlkpsnlavnedselkildfglarhtddemtgyvat
rwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgae
llkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqalah
ayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeeme

Sequence, based on observed residues (ATOM records):

>d6spla_ d.144.1.7 (A:) MAP kinase p38 {Mouse (Mus musculus) [TaxId: 10090]}
ptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsiiha
krtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltdd
hvqfliyqilrglkyihsadiihrdlkpsnlavnedselkildfglryvatrwyrapeim
lnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkisses
arnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhdp
ddepvadpydqsfesrdllidewksltydevisfvpppldqeeme

Timeline for d6spla_:

• d6spla_ first appeared in SCOPe 2.07