SCOPe 2.08: Domain d6hmra_: 6hmr A:

Lineage for d6hmra_ (6hmr A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Casein kinase-1, CK1 [56139] (4 species)
   OPK group; CKI subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [224941] (25 PDB entries)

8. Domain d6hmra_: 6hmr A: [373993]
   Other proteins in same PDB: d6hmrb2
   automated match to d1ckia_
   complexed with ge5, mla

Details for d6hmra_

PDB Entry: 6hmr, 1.78 Å

PDB Description: crystal structure of human casein kinase i delta in complex with a photoswitchable 2-azothiazole-based inhibitor (compound 2)

PDB Compounds: (A:) Casein kinase I isoform delta

SCOPe Domain Sequences for d6hmra_:

Sequence, based on SEQRES records:

>d6hmra_ d.144.1.7 (A:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
nryrlgrkigsgsfgdiylgtdiaageevaiklecvktkhpqlhieskiykmmqggvgip
tirwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfih
rdvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthl
gieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgyps
efatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk

Sequence, based on observed residues (ATOM records):

>d6hmra_ d.144.1.7 (A:) Casein kinase-1, CK1 {Human (Homo sapiens) [TaxId: 9606]}
nryrlgrkigsgsfgdiylgtdiaaeevaiklecvktkhpqlhieskiykmmqggvgipt
irwcgaegdynvmvmellgpsledlfnfcsrkfslktvllladqmisrieyihsknfihr
dvkpdnflmglgkkgnlvyiidfglakkyrdarthqhipyrenknltgtaryasinthlg
ieqsrrddleslgyvlmyfnlgslpwqglkaatkrqkyerisekkmstpievlckgypse
fatylnfcrslrfddkpdysylrqlfrnlfhrqgfsydyvfdwnmlk

Timeline for d6hmra_:

• d6hmra_ first appeared in SCOPe 2.07