SCOPe 2.08: Domain d6p68b_: 6p68 B:

Lineage for d6p68b_ (6p68 B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (47 PDB entries)

8. Domain d6p68b_: 6p68 B: [371221]
   automated match to d4v04b_
   complexed with o1y, so4

Details for d6p68b_

PDB Entry: 6p68, 2.9 Å

PDB Description: crystal structure of fgfr1-y563c (fgfr4 surrogate) covalently bound to compound 22.

PDB Compounds: (B:) fibroblast growth factor receptor 1

SCOPe Domain Sequences for d6p68b_:

Sequence, based on SEQRES records:

>d6p68b_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
eyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdat
ekdlsdlisememmkmigkhkniinllgactqdgplyvivecaskgnlreylqarrppgl
eysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiad
fglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspy
pgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivalt
sn

Sequence, based on observed residues (ATOM records):

>d6p68b_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
eyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdat
ekdlsdlisememmkmigkhkniinllgactqdgplyvivecaskgnlreylqarrpeeq
lsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardidyykkt
tngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkegh
rmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsn

Timeline for d6p68b_:

• d6p68b_ first appeared in SCOPe 2.07