SCOPe 2.08: Domain d6mh2c2: 6mh2 C:108-214

Lineage for d6mh2c2 (6mh2 C:108-214)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (147 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d6mh2c2: 6mh2 C:108-214 [369405]
   Other proteins in same PDB: d6mh2a1, d6mh2b_, d6mh2c1, d6mh2d_
   automated match to d1n8za2

Details for d6mh2c2

PDB Entry: 6mh2, 2.8 Å

PDB Description: structure of herceptin fab without antigen

PDB Compounds: (C:) Herceptin Fab arm light chain

SCOPe Domain Sequences for d6mh2c2:

Sequence, based on SEQRES records:

>d6mh2c2 b.1.1.2 (C:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Sequence, based on observed residues (ATOM records):

>d6mh2c2 b.1.1.2 (C:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppasvvcllnnfypreakvqwgnsqesvteqdskdstyslsstltlska
dyekhkvyacevthqglsspvtksfnrgec

Timeline for d6mh2c2:

• d6mh2c2 first appeared in SCOPe 2.07