SCOPe 2.08: Domain d6cxsb3: 6cxs B:276-599

Lineage for d6cxsb3 (6cxs B:276-599)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (15 families)

5. Family c.1.8.0: automated matches [191314] (1 protein)
   not a true family

6. Protein automated matches [190075] (132 species)
   not a true protein

7. Species Clostridium perfringens [TaxId:195102] [267956] (2 PDB entries)

8. Domain d6cxsb3: 6cxs B:276-599 [367703]
   Other proteins in same PDB: d6cxsa1, d6cxsa2, d6cxsa4, d6cxsb1, d6cxsb2, d6cxsb4, d6cxsd1, d6cxsd2
   automated match to d4jkla3
   complexed with fjv

Details for d6cxsb3

PDB Entry: 6cxs, 2.8 Å

PDB Description: crystal structure of clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4- tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl) morpholine

PDB Compounds: (B:) beta-glucuronidase

SCOPe Domain Sequences for d6cxsb3:

Sequence, based on SEQRES records:

>d6cxsb3 c.1.8.0 (B:276-599) automated matches {Clostridium perfringens [TaxId: 195102]}
vevkdgkflinnkpfyfkgfgkhedsyvngrgineainikdfnlmkwigansfrtshypy
seeimrladregivvidetpavglhlnfmatgfggdapkrdtwkeigtkeaherilrelv
srdknhpcvvmwsvanepdsdsegakeyfeplikltkeldpqkrpvtvvtylmstpdrck
vgdivdvlclnryygwyvaggdleeakrmledelkgweercpktpimfteygadtvaglh
dtvpvmfteeyqveyykanhevmdkcknfvgeqvwnfadfatsqgiirvqgnkkgiftre
rkpkmiahslrerwtnipefgykk

Sequence, based on observed residues (ATOM records):

>d6cxsb3 c.1.8.0 (B:276-599) automated matches {Clostridium perfringens [TaxId: 195102]}
vevkdgkflinnkpfyfkgfgkhedsyvngrgineainikdfnlmkwigansfrtshypy
seeimrladregivvidetpavglhlnfmatgfapkrdtwkeigtkeaherilrelvsrd
knhpcvvmwsvanepdsdsegakeyfeplikltkeldpqkrpvtvvtylmstpdrckvgd
ivdvlclnryygwyvaggdleeakrmledelkgweercpktpimfteygadtvaglhdtv
pvmfteeyqveyykanhevmdkcknfvgeqvwnfadfatsqgiirvqgnkkgiftrerkp
kmiahslrerwtnipefgykk

Timeline for d6cxsb3:

• d6cxsb3 first appeared in SCOPe 2.07