SCOPe 2.08: Domain d6hrta_: 6hrt A:

Lineage for d6hrta_ (6hrt A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d6hrta_: 6hrt A: [366553]
   automated match to d5j87b_
   complexed with gmw

Details for d6hrta_

PDB Entry: 6hrt, 1.36 Å

PDB Description: crystal structure of btk kinase domain complexed with 12-(6-tert- butyl-8-fluoro-1-oxo-phthalazin-2-yl)-9-hydroxy-6-methyl-4-[[5- (morpholine-4-carbonyl)-2-pyridyl]amino]-6-azatricyclo[9.4.0.02, 7]pentadeca-1(15),2(7),3,11,13-pentaen-5-one

PDB Compounds: (A:) Tyrosine-protein kinase BTK

SCOPe Domain Sequences for d6hrta_:

Sequence; same for both SEQRES and ATOM records:

>d6hrta_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eidpkdltflkelgtgqfgvvkygkwrgqydvaikmikegsmsedefieeakvmmnlshe
klvqlygvctkqrpifiiteymangcllnylrearhafqtqqllemckdvceameylesk
qflhrdlaarnclvndqgvvkvsdfglsryvlddeytssvgskfpvrwsppevlmyskfs
sksdiwafgvlmweiyslgkmpyerftnsetaehiaqglrlyrphlasaavytimyscwh
ekaderptfkillsnildvmdee

Timeline for d6hrta_:

• d6hrta_ first appeared in SCOPe 2.07