SCOPe 2.08: Domain d6npua1: 6npu A:265-519

Lineage for d6npua1 (6npu A:265-519)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d6npua1: 6npu A:265-519 [366337]
   Other proteins in same PDB: d6npua2, d6npub2
   automated match to d2f4ja_
   complexed with 2pe, gol, kwv, so4, sti

Details for d6npua1

PDB Entry: 6npu, 2.33 Å

PDB Description: c-abl kinase domain with the activator(cmpd29), n-(1-(3,4- dichlorophenyl)-4,5-dihydro-1h-pyrazol-3-yl)acetamide

PDB Compounds: (A:) Tyrosine-protein kinase ABL1

SCOPe Domain Sequences for d6npua1:

Sequence, based on SEQRES records:

>d6npua1 d.144.1.7 (A:265-519) automated matches {Human (Homo sapiens) [TaxId: 9606]}
hklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkeikhpnlvqllgvc
treppfyiitefmtygnlldylrecnrqevnavvllymatqissameylekknfihrdla
arnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfsiksdvwaf
gvllweiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsdrps
faeihqafetmfqes

Sequence, based on observed residues (ATOM records):

>d6npua1 d.144.1.7 (A:265-519) automated matches {Human (Homo sapiens) [TaxId: 9606]}
hklgggqygevyegvwkkysltvavktlkveeflkeaavmkeikhpnlvqllgvctrepp
fyiitefmtygnlldylrecnrqevnavvllymatqissameylekknfihrdlaarncl
vgenhlvkvadfglsrlmtgdtytahagakfpikwtapeslaynkfsiksdvwafgvllw
eiatygmspypgidlsqvyellekdyrmerpegcpekvyelmracwqwnpsdrpsfaeih
qafetmfqes

Timeline for d6npua1:

• d6npua1 first appeared in SCOPe 2.07