SCOPe 2.08: Domain d6ngfa_: 6ngf A:

Lineage for d6ngfa_ (6ngf A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.174: Nitric oxide (NO) synthase oxygenase domain [56511] (1 superfamily)
   unusual fold

4. Superfamily d.174.1: Nitric oxide (NO) synthase oxygenase domain [56512] (1 family)
   automatically mapped to Pfam PF02898

5. Family d.174.1.1: Nitric oxide (NO) synthase oxygenase domain [56513] (2 proteins)

6. Protein automated matches [190421] (6 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187302] (89 PDB entries)

8. Domain d6ngfa_: 6ngf A: [366173]
   automated match to d4ucha_
   complexed with gol, h4b, hem, kn4, zn; mutant

Details for d6ngfa_

PDB Entry: 6ngf, 1.99 Å

PDB Description: structure of human neuronal nitric oxide synthase r354a/g357d mutant heme domain in complex with (r)-6-(2,3-difluoro-5-(2-(1- methylpyrrolidin-2-yl)ethyl)phenethyl)-4-methylpyridin-2-amine

PDB Compounds: (A:) Nitric oxide synthase, brain

SCOPe Domain Sequences for d6ngfa_:

Sequence, based on SEQRES records:

>d6ngfa_ d.174.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpsqharrpedvatkdqlfp
lakefidqyyssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcv
griqwsklqvfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwn
sqliryagykqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqi
ppelvlevpirhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvr
dycdnsrynileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsate
sfikhmeneyrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvw
k

Sequence, based on observed residues (ATOM records):

>d6ngfa_ d.174.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
cprflkvknwetevvltdtlhlkstletgcteyicmgsimhpdvatkdqlfplakefidq
yyssikrfgskahmerleevnkeidttstyqlkdteliygakhawrnasrcvgriqwskl
qvfdardcttahgmfnyicnhvkyatnkgnlrsaitifpqrtdgkhdfrvwnsqliryag
ykqpdgstlgdpanvqfteiciqqgwkpprgrfdvlplllqangndpelfqippelvlev
pirhpkfewfkdlglkwyglpavsnmlleigglefsacpfsgwymgteigvrdycdnsry
nileevakkmnldmrktsslwkdqalveiniavlysfqsdkvtivdhhsatesfikhmen
eyrcrggcpadwvwivppmsgsitpvfhqemlnyrltpsfeyqpdpwnthvwk

Timeline for d6ngfa_:

• d6ngfa_ first appeared in SCOPe 2.07