Lineage for d6hwez_ (6hwe Z:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2548740Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. 2548741Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (8 families) (S)
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
  5. 2548925Family d.153.1.4: Proteasome subunits [56251] (4 proteins)
  6. 2550690Protein Proteasome beta subunit (catalytic) [56252] (7 species)
  7. 2550699Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [56254] (199 PDB entries)
    The structure of yeast proteasome complexed with the proteasome activator pa26 is available from PDB (1fnt). The 1FNT entry designates protein chains by both upper case and lower case letters creating problems with its processing and presentation in SCOP; the proteasome activator pa26 structure is classified elsewhere in SCOP (a.24.8)
  8. 3064012Domain d6hwez_: 6hwe Z: [364074]
    Other proteins in same PDB: d6hwea_, d6hwec_, d6hwed_, d6hwee_, d6hwef_, d6hweg_, d6hweh_, d6hwem_, d6hweo_, d6hwep_, d6hweq_, d6hwer_, d6hwes_, d6hwet_, d6hweu_, d6hwev_
    automated match to d1rypm_
    complexed with cl, gwz, mes, mg, so4; mutant

Details for d6hwez_

PDB Entry: 6hwe (more details), 2.3 Å

PDB Description: yeast 20s proteasome beta2-g45a mutant in complex with carfilzomib
PDB Compounds: (Z:) Proteasome subunit beta type-6

SCOPe Domain Sequences for d6hwez_:

Sequence; same for both SEQRES and ATOM records: (download)

>d6hwez_ d.153.1.4 (Z:) Proteasome beta subunit (catalytic) {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
qfnpygdnggtilgiagedfavlagdtrnitdysinsryepkvfdcgdnivmsangfaad
gdalvkrfknsvkwyhfdhndkklsinsaarniqhllygkrffpyyvhtiiagldedgkg
avysfdpvgsyereqcraggaaaslimpfldnqvnfknqyepgtngkvkkplkylsveev
iklvrdsftsaterhiqvgdgleilivtkdgvrkefyelkrd

SCOPe Domain Coordinates for d6hwez_:

Click to download the PDB-style file with coordinates for d6hwez_.
(The format of our PDB-style files is described here.)

Timeline for d6hwez_:

  • d6hwez_ appears in periodic updates to SCOPe 2.07 starting on 2019-02-09