SCOPe 2.08: Domain d6fh5a3: 6fh5 A:726-1087

Lineage for d6fh5a3 (6fh5 A:726-1087)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (78 PDB entries)

8. Domain d6fh5a3: 6fh5 A:726-1087 [363308]
   Other proteins in same PDB: d6fh5a1, d6fh5a2
   automated match to d1he8a4
   complexed with dd8

Details for d6fh5a3

PDB Entry: 6fh5, 2.84 Å

PDB Description: pi3kg in complex with compound 7

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d6fh5a3:

Sequence, based on SEQRES records:

>d6fh5a3 d.144.1.4 (A:726-1087) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wf

Sequence, based on observed residues (ATOM records):

>d6fh5a3 d.144.1.4 (A:726-1087) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsassqvisqlkqklenlqnlpesfrvpydpglk
agalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrime
siwetesldlcllpygcistgdkigmieivkdattiakiqqkdevlnhwlkekspteekf
qaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghervpfvltpdflfv
mgtsgtsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmkedieyirdaltvgkne
edakkyfldqievcrdkgwtvqfnwf

Timeline for d6fh5a3:

• d6fh5a3 first appeared in SCOPe 2.07