SCOPe 2.08: Domain d6c18b_: 6c18 B:

Lineage for d6c18b_ (6c18 B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (47 PDB entries)

8. Domain d6c18b_: 6c18 B: [362166]
   automated match to d4v04b_
   complexed with so4, yy5

Details for d6c18b_

PDB Entry: 6c18, 2.3 Å

PDB Description: fgfr1 kinase complex with inhibitor sn37115

PDB Compounds: (B:) fibroblast growth factor receptor 1

SCOPe Domain Sequences for d6c18b_:

Sequence, based on SEQRES records:

>d6c18b_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
pedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatekdl
sdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgleysy
npshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgla
rdihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvp
veelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivalts

Sequence, based on observed residues (ATOM records):

>d6c18b_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
pedprwelprdrlvlgkplggqvvlaeaigldkpnrvtkvavkmlksdatekdlsdlise
memmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrqlsskdlvscayqv
argmeylaskkcihrdlaarnvlvtednvmkiadfpvkwmapealfdriythqsdvwsfg
vllweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptf
kqlvedldrivalts

Timeline for d6c18b_:

• d6c18b_ first appeared in SCOPe 2.07