SCOPe 2.08: Domain d6c1bb_: 6c1b B:

Lineage for d6c1bb_ (6c1b B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Fibroblast growth factor receptor 1 [56158] (1 species)
   PTK group; FGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56159] (47 PDB entries)

8. Domain d6c1bb_: 6c1b B: [362052]
   automated match to d4v04b_
   complexed with yy4

Details for d6c1bb_

PDB Entry: 6c1b, 2 Å

PDB Description: fgfr1 kinase complex with inhibitor sn37118

PDB Compounds: (B:) fibroblast growth factor receptor 1

SCOPe Domain Sequences for d6c1bb_:

Sequence, based on SEQRES records:

>d6c1bb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
yelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdate
kdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgle
ysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadf
glardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspyp
gvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivalts

Sequence, based on observed residues (ATOM records):

>d6c1bb_ d.144.1.7 (B:) Fibroblast growth factor receptor 1 {Human (Homo sapiens) [TaxId: 9606]}
yelpedprwelprdrlvlgkplgegqvvlaeairvtkvavkmlksdatekdlsdliseme
mmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrqlsskdlvscayqvar
gmeylaskkcihrdlaarnvlvtednvmkiadfgllpvkwmapealfdriythqsdvwsf
gvllweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrpt
fkqlvedldrivalts

Timeline for d6c1bb_:

• d6c1bb_ first appeared in SCOPe 2.07