Lineage for d6ecza_ (6ecz A:)

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2401367Fold b.74: Carbonic anhydrase [51068] (1 superfamily)
    single sheet; 10 strands
  4. 2401368Superfamily b.74.1: Carbonic anhydrase [51069] (2 families) (S)
  5. 2401369Family b.74.1.1: Carbonic anhydrase [51070] (2 proteins)
    automatically mapped to Pfam PF00194
  6. 2401370Protein Carbonic anhydrase [51071] (10 species)
  7. 2401409Species Human (Homo sapiens), erythrocytes, isozyme II [TaxId:9606] [51073] (756 PDB entries)
    Uniprot P00918
  8. 3060533Domain d6ecza_: 6ecz A: [360595]
    automated match to d2foua_
    complexed with j4d, zn

Details for d6ecza_

PDB Entry: 6ecz (more details), 2.21 Å

PDB Description: bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms ix and xii and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
PDB Compounds: (A:) Carbonic anhydrase 2

SCOPe Domain Sequences for d6ecza_:

Sequence; same for both SEQRES and ATOM records: (download)

>d6ecza_ b.74.1.1 (A:) Carbonic anhydrase {Human (Homo sapiens), erythrocytes, isozyme II [TaxId: 9606]}
hwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnng
hafnvefddsqdkavlkggpldgtyrliqfhfhwgsldgqgsehtvdkkkyaaelhlvhw
ntkygdfgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdprgl
lpesldywtypgslttppllecvtwivlkepisvsseqvlkfrklnfngegepeelmvdn
wrpaqplknrqikasfk

SCOPe Domain Coordinates for d6ecza_:

Click to download the PDB-style file with coordinates for d6ecza_.
(The format of our PDB-style files is described here.)

Timeline for d6ecza_:

  • d6ecza_ appears in periodic updates to SCOPe 2.07 starting on 2018-11-29