SCOPe 2.08: Domain d6hd4a1: 6hd4 A:248-529

Lineage for d6hd4a1 (6hd4 A:248-529)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Abelsone tyrosine kinase (abl) [56166] (2 species)
   PTK group; Abl subfamily; non-membrane spanning protein tyrosine kinase

7. Species Mouse (Mus musculus) [TaxId:10090] [56167] (16 PDB entries)

8. Domain d6hd4a1: 6hd4 A:248-529 [359296]
   Other proteins in same PDB: d6hd4a2, d6hd4b2
   automated match to d1m52b_
   complexed with cl, fyw, gol, sti

Details for d6hd4a1

PDB Entry: 6hd4, 2.03 Å

PDB Description: abl1 in complex with compound 7 and imatinib (sti-571)

PDB Compounds: (A:) Tyrosine-protein kinase ABL1

SCOPe Domain Sequences for d6hd4a1:

Sequence, based on SEQRES records:

>d6hd4a1 d.144.1.7 (A:248-529) Abelsone tyrosine kinase (abl) {Mouse (Mus musculus) [TaxId: 10090]}
spnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaa
vmkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqis
sameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtap
eslaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekv
yelmracwqwnpsdrpsfaeihqafetmfqessisdevekel

Sequence, based on observed residues (ATOM records):

>d6hd4a1 d.144.1.7 (A:248-529) Abelsone tyrosine kinase (abl) {Mouse (Mus musculus) [TaxId: 10090]}
spnydkwemertditmkhklgggqygevyegvwkkysltvavktlkedmeveeflkeaav
mkeikhpnlvqllgvctreppfyiitefmtygnlldylrecnrqevsavvllymatqiss
ameylekknfihrdlaarnclvgenhlvkvadfglsrlmtgdtytahagakfpikwtape
slaynkfsiksdvwafgvllweiatygmspypgidlsqvyellekdyrmerpegcpekvy
elmracwqwnpsdrpsfaeihqafetmfqessisdevekel

Timeline for d6hd4a1:

• d6hd4a1 first appeared in SCOPe 2.07