Lineage for d5yqoa1 (5yqo A:56-356)

  1. Root: SCOPe 2.07
  2. 2413226Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2444630Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. 2444631Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families) (S)
    binds cofactor molecules in the opposite direction than classical Rossmann fold
  5. 2444911Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 proteins)
    silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain
  6. 2444971Protein Sirt2 histone deacetylase [63987] (1 species)
  7. 2444972Species Human (Homo sapiens) [TaxId:9606] [63988] (20 PDB entries)
  8. 3058988Domain d5yqoa1: 5yqo A:56-356 [359050]
    Other proteins in same PDB: d5yqoa2
    automated match to d1j8fc_
    complexed with l5c, zn

Details for d5yqoa1

PDB Entry: 5yqo (more details), 1.48 Å

PDB Description: crystal structure of sirt2 in complex with selective inhibitor l5c
PDB Compounds: (A:) nad-dependent protein deacetylase sirtuin-2

SCOPe Domain Sequences for d5yqoa1:

Sequence, based on SEQRES records: (download)

>d5yqoa1 c.31.1.5 (A:56-356) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
erlldeltlegvarymqsercrrviclvgagistsagipdfrspstglydnlekyhlpyp
eaifeisyfkkhpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleri
agleqedlveahgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivff
geslparffscmqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdp
flgmimglgggmdfdskkayrdvawlgecdqgclalaellgwkkeledlvrrehasidaq
s

Sequence, based on observed residues (ATOM records): (download)

>d5yqoa1 c.31.1.5 (A:56-356) Sirt2 histone deacetylase {Human (Homo sapiens) [TaxId: 9606]}
erlldeltlegvarymqsercrrviclvgagistsagipdfrspstpypeaifeisyfkk
hpepffalakelypgqfkptichyfmrllkdkglllrcytqnidtleriagleqedlvea
hgtfytshcvsascrheyplswmkekifsevtpkcedcqslvkpdivffgeslparffsc
mqsdflkvdlllvmgtslqvqpfasliskaplstprllinkekagqsdpflggmdfdskk
ayrdvawlgecdqgclalaellgwkkeledlvrrehasidaqs

SCOPe Domain Coordinates for d5yqoa1:

Click to download the PDB-style file with coordinates for d5yqoa1.
(The format of our PDB-style files is described here.)

Timeline for d5yqoa1:

  • d5yqoa1 appears in periodic updates to SCOPe 2.07 starting on 2018-10-18

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Domains from same chain:
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d5yqoa2