Lineage for d6hm6a_ (6hm6 A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2542316Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2545010Protein Tyrosine-protein kinase SYK [118131] (1 species)
    PTK group; SYK/ZAP-70 subfamily; non-membrane spanning protein tyrosine kinase
  7. 2545011Species Human (Homo sapiens) [TaxId:9606] [118132] (63 PDB entries)
    Uniprot P43405 363-635 # structure of the SH2 domain tandem region (9-265) is also known (55576)
  8. 3058685Domain d6hm6a_: 6hm6 A: [358747]
    automated match to d3tuca_
    complexed with gdk, gol

Details for d6hm6a_

PDB Entry: 6hm6 (more details), 2.1 Å

PDB Description: crystal structure of spleen tyrosine kinase (syk) in complex with a 2- (pyridinyloxymethyl)pyridine inhibitor
PDB Compounds: (A:) spleen tyrosine kinase

SCOPe Domain Sequences for d6hm6a_:

Sequence, based on SEQRES records: (download)

>d6hm6a_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
yldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpalkdellaeanv
mqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmk
yleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthgkwpvkwyapec
inyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremyd
lmnlcwtydvenrpgfaavelrlrnyyyd

Sequence, based on observed residues (ATOM records): (download)

>d6hm6a_ d.144.1.7 (A:) Tyrosine-protein kinase SYK {Human (Homo sapiens) [TaxId: 9606]}
yldrklltledkelgsgnfgtvkkgyyqmkvvktvavkildpalkdellaeanvmqqldn
pyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkyleesn
fvhrdlaarnvllvtqhyakisdfglskalradenyykaqgkwpvkwyapecinyykfss
ksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwty
dvenrpgfaavelrlrnyyyd

SCOPe Domain Coordinates for d6hm6a_:

Click to download the PDB-style file with coordinates for d6hm6a_.
(The format of our PDB-style files is described here.)

Timeline for d6hm6a_:

  • d6hm6a_ appears in periodic updates to SCOPe 2.07 starting on 2018-10-11