Lineage for d6h3ka1 (6h3k A:519-794)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2546221Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2546222Protein automated matches [190417] (28 species)
    not a true protein
  7. 2546365Species Human (Homo sapiens) [TaxId:9606] [187294] (1001 PDB entries)
  8. 3057738Domain d6h3ka1: 6h3k A:519-794 [357800]
    Other proteins in same PDB: d6h3ka2
    automated match to d5ei2a_
    complexed with 7pe, fmw

Details for d6h3ka1

PDB Entry: 6h3k (more details), 2.48 Å

PDB Description: introduction of a methyl group curbs metabolism of pyrido[3,4- d]pyrimidine mps1 inhibitors and enables the discovery of the phase 1 clinical candidate bos172722.
PDB Compounds: (A:) Dual specificity protein kinase TTK

SCOPe Domain Sequences for d6h3ka1:

Sequence, based on SEQRES records: (download)

>d6h3ka1 d.144.1.0 (A:519-794) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiaylnkl
qqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleavhti
hqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnymppeaikdm
sssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnheiefpd
ipekdlqdvlkcclkrdpkqrisipellahpyvqiq

Sequence, based on observed residues (ATOM records): (download)

>d6h3ka1 d.144.1.0 (A:519-794) automated matches {Human (Homo sapiens) [TaxId: 9606]}
svkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiaylnkl
qqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleavhti
hqhgivhsdlkpanflivdgmlklidfgianqmqptvnymppeaikdmskispksdvwsl
gcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpkqri
sipellahpyvqiq

SCOPe Domain Coordinates for d6h3ka1:

Click to download the PDB-style file with coordinates for d6h3ka1.
(The format of our PDB-style files is described here.)

Timeline for d6h3ka1:

  • d6h3ka1 appears in periodic updates to SCOPe 2.07 starting on 2018-09-20

View in 3D
Domains from same chain:
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d6h3ka2