SCOPe 2.08: Domain d6bfqk1: 6bfq K:19-110

Lineage for d6bfqk1 (6bfq K:19-110)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Granulocyte-macrophage colony-stimulating factor (GM-CSF) [47289] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47290] (10 PDB entries)

8. Domain d6bfqk1: 6bfq K:19-110 [357336]
   Other proteins in same PDB: d6bfqa_, d6bfqb1, d6bfqb2, d6bfqc_, d6bfqd1, d6bfqd2, d6bfqe_, d6bfqf1, d6bfqf2, d6bfqg2, d6bfqh_, d6bfqi2, d6bfqj2, d6bfqk2, d6bfql1, d6bfql2
   automated match to d5d22b_

Details for d6bfqk1

PDB Entry: 6bfq, 2.6 Å

PDB Description: the mechanism of gm-csf inhibition by human gm-csf auto-antibodies

PDB Compounds: (K:) granulocyte-macrophage colony-stimulating factor

SCOPe Domain Sequences for d6bfqk1:

Sequence, based on SEQRES records:

>d6bfqk1 a.26.1.2 (K:19-110) Granulocyte-macrophage colony-stimulating factor (GM-CSF) {Human (Homo sapiens) [TaxId: 9606]}
iqearrllnlsrdtaaemnetvevisemfdlqeptclqtrlelykqglrgsltklkgplt
mmashykqhcpptpetscatqiitfesfkenl

Sequence, based on observed residues (ATOM records):

>d6bfqk1 a.26.1.2 (K:19-110) Granulocyte-macrophage colony-stimulating factor (GM-CSF) {Human (Homo sapiens) [TaxId: 9606]}
iqearrllnlsraemnetvevisemfdlqeptclqtrlelykqglrgsltklkgpltmma
shykqhcpptpetscatqiitfesfkenl

Timeline for d6bfqk1:

• d6bfqk1 first appeared in SCOPe 2.07